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Third Harmonic Bio · pitchdeck

Third Harmonic Bio | IPO Presentation Deck | 24 slides

24 pages · 3 arc beats · 2 loops

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Third Harmonic Bio | IPO Presentation Deck | 24 slides

Third Harmonic Bio · 2022-09
arc beats above · slides in the middle · loops below · scroll → 2 LOOPS
SETUP TENSION ANALYSIS EVIDENCE RESOLUTION APPENDIX
HOVER FOR DETAILS · CLICK A SLIDE FOR FULLSCREEN · STEP 1
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Deck intelligence map

3
coverage by narrative range · generated from this deck JSON
Narrative range 6 total
Metadata
Components
Metrics
Tools
Frameworks
Beats
Loops
Problem 2 slides 100% 2/2 slides 100% 2/2 slides · 11 hits
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100% 2/2 slides 50% 1/2 slides 100% 2/2 slides 100% 2/2 slides Solution 2 slides 100% 2/2 slides 100% 2/2 slides · 9 hits
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50% 1/2 slides 50% 1/2 slides 100% 2/2 slides 100% 2/2 slides Market Size 2 slides 100% 2/2 slides 100% 2/2 slides · 11 hits
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100% 2/2 slides 100% 2/2 slides · 4 hits

Slide inventory

24
every slide · same image gating as the playbook
01
Slide 1
front_matter
Open slide detail
02
other
Open slide detail
03
summarize
Open slide detail
04
summarize
Open slide detail
05
The slide uses a central hub-and-spoke diagram to show the mast cell as the central point of failure/intervention.frame_problem
Open slide detailBeat · ProblemLoop · Cost Of Inaction
06
The data highlights the mechanism of action of KIT inhibition (inactivation and depletion) supported by Phase 1b interim results.show_traction
Open slide detailBeat · ProblemLoop · Cost Of Inaction
07
The slide presents a summary of preclinical efficacy and safety data alongside a table demonstrating high selectivity against other kinases.present_solution
Open slide detailBeat · SolutionLoop · Cost Of Inaction
08
The slide uses a staircase diagram to represent dose escalation and a crossover diagram for the food effect study.plan_implementation
Open slide detailBeat · SolutionLoop · Cost Of Inaction
09
The chart displays multiple dose cohorts (200mg QD, 200mg BID, 400mg BID, 500mg QD FED) with error bars representing standard deviation.analyze_data
Open slide detailLoop · Cost Of Inaction
10
The table displays counts and percentages of subjects experiencing specific adverse events. 'MAD' stands for Multiple Ascending Dose.analyze_data
Open slide detailLoop · Cost Of Inaction
11
The chart tracks neutrophil levels across multiple cohorts (placebo, 200mg QD, 200mg Q12H, 400mg Q12H, 500mg QD FED) from Day 1 to Day 70/EOS, with a vertical lanalyze_data
Open slide detailLoop · Cost Of Inaction
12
The slide includes a disclaimer that cross-study comparisons are unreliable due to differences in study design.analyze_data
Open slide detailLoop · Cost Of Inaction
13
Includes two line charts: one normalized to baseline and one showing absolute values.analyze_data
Open slide detailLoop · Cost Of Inaction
14
The schematic illustrates a dose escalation study with three cohorts of 10 patients each, separated by safety review committee (SRC) checkpoints.plan_implementation
Open slide detailLoop · Cost Of Inaction
15
The chart shows a pharmacokinetic (PK) profile comparing two formulations of THB001.analyze_data
Open slide detailLoop · Cost Of Inaction
16
The slide uses clinical data to justify a new indication for a drug candidate by highlighting the role of mast cells in asthma pathophysiology.establish_context
Open slide detailLoop · Cost Of Inaction
17
The slide outlines a randomized, placebo-controlled trial structure with specific allergen challenge points.plan_implementation
Open slide detailLoop · Cost Of Inaction
18
The slide uses a timeline diagram to show clinical phases and key events (trial initiation, regulatory submission, data readout) from 2H'22 to 2H'24.plan_implementation
Open slide detailLoop · Cost Of Inaction
19
appendix
Open slide detailLoop · Cost Of Inaction
20
Includes a patient quote and clinical imagery to emphasize the severity of the condition.frame_problem
Open slide detailBeat · Market SizeLoop · Cost Of Inaction
21
Includes medical imagery of lungs and mast cells.frame_problem
Open slide detailBeat · Market SizeLoop · Cost Of Inaction
22
DART stands for developmental and reproductive toxicology.analyze_data
Open slide detailLoop · Quick Win Big Bet
23
SAD = Single Ascending Dose; FE = Food Effect; PK = Pharmacokinetics; SAE = Serious Adverse Event; AE = Adverse Event; PBO = Placebo.analyze_data
Open slide detailLoop · Quick Win Big Bet
24
MAD = Multiple Ascending Dose study. Data shows transient changes in reticulocytes and hemoglobin levels during treatment.analyze_data
Open slide detailLoop · Quick Win Big Bet