Genprex | Investor Presentation Deck | 58 slides

Genprex · 2024-11
arc beats above · slides in the middle · loops below · scroll → 2 LOOPS
SETUP TENSION ANALYSIS EVIDENCE RESOLUTION APPENDIX
HOVER FOR DETAILS · CLICK A SLIDE FOR FULLSCREEN · STEP 2
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Slide inventory

58
every slide · same image gating as the playbook
01
Slide 1
front_matter
Open slide detailBeat · Attention
02
other
Open slide detailBeat · Attention
03
inspire_vision
Open slide detailBeat · Attention
04
summarize
Open slide detailBeat · Attention
05
The slide uses a Gantt-style visualization to show the progress of various drug candidates through clinical phases.plan_implementation
Open slide detailBeat · Need
06
front_matter
Open slide detailBeat · Need
07
Includes a cytogenetic map showing the 600kb deletion region on chromosome 3.establish_context
Open slide detailBeat · NeedLoop · Golden Circle
08
Uses a 'brake pedal' analogy to explain biological function.frame_problem
Open slide detailBeat · NeedLoop · Golden Circle
09
The slide uses a process diagram to illustrate the mechanism of action for REQORSA gene therapy.present_solution
Open slide detailBeat · NeedLoop · Golden Circle
10
The process is presented as a sequential workflow.present_solution
Open slide detailBeat · Satisfaction
11
The slide uses a hub-and-spoke visual metaphor to connect the central platform to three key value propositions.present_solution
Open slide detailBeat · Satisfaction
12
The slide uses a numbered list format to explain the mechanism of action.present_solution
Open slide detailBeat · Satisfaction
13
The slide uses a line chart (Seahorse XF Glycolysis Stress Test profile) and a bar chart to show metabolic impact.present_solution
Open slide detailBeat · Satisfaction
14
The slide uses a series of circles to present key metrics, highlighting the global market size as the central focus.size_opportunity
Open slide detailBeat · Satisfaction
15
ONC-001 Trialshow_traction
Open slide detailBeat · Satisfaction
16
The slide uses fluorescence microscopy images to show the mechanism of action (selective uptake) of the drug.present_solution
Open slide detailBeat · Satisfaction
17
The trial met Simon 2-stage criteria but was discontinued to prioritize a study with Tagrisso.show_traction
Open slide detailBeat · Satisfaction
18
The slide uses a 'problem-solution' framing, highlighting the limitation of existing drugs and the mechanism of the company's therapy.frame_problem
Open slide detailBeat · SatisfactionLoop · Cost Of Inaction
19
The slide includes a timeline of the study and two line charts showing tumor volume over time for different treatment groups.show_traction
Open slide detailBeat · SatisfactionLoop · Cost Of Inaction
20
The slide outlines a multi-phase clinical trial structure (Phase 1, 2a, 2b) and provides specific patient counts and interim analysis milestones.show_traction
Open slide detailBeat · SatisfactionLoop · Cost Of Inaction
21
Includes a table of enrollment/DLTs and a swimmer plot for PFS.show_traction
Open slide detailBeat · Visualization
22
Includes a histological image showing negative TUSC2 expression.present_solution
Open slide detailBeat · Visualization
23
The table highlights a statistically significant difference (p=0.0008) in TUSC2 protein expression between SCLC and NSCLC.frame_problem
Open slide detailBeat · Visualization
24
Includes Kaplan-Meier curves for Overall Survival (A) and Progression-free Survival (B).show_traction
Open slide detailBeat · Visualization
25
Kaplan-Meier survival curve showing PFS. Mentions Tecentriq as brand name for Atezolizumab.show_traction
Open slide detailBeat · Visualization
26
Includes bioluminescence imaging and quantitative bar chart with statistical significance markers (p-values).show_traction
Open slide detailBeat · Visualization
27
The slide shows four separate bar charts comparing Control, Atezo (Tecentriq), REQORSA, and Combination therapies across four immune cell types.show_traction
Open slide detailBeat · Visualization
28
Clinical trial design slide for a pharmaceutical study.plan_implementation
Open slide detailBeat · Visualization
29
The chart shows statistical significance (p-values) comparing treatment groups against controls.show_traction
Open slide detailBeat · Visualization
30
The chart shows tumor volume over time (days) for four groups, demonstrating synergistic efficacy of the dual gene therapy.present_solution
Open slide detailBeat · Visualization
31
transition
Open slide detailBeat · Visualization
32
The slide uses a series of circles to present key metrics, highlighting the global expenditure figure.size_opportunity
Open slide detailBeat · Visualization
33
Uses an emotional image of a father and child to emphasize the human impact of the disease.frame_problem
Open slide detailBeat · Visualization
34
frame_problem
Open slide detailBeat · Visualization
35
Uses a timeline to establish a 'gap' in innovation, followed by three key arguments for why new therapy is needed.argue_timing
Open slide detailBeat · Visualization
36
The slide uses a pie chart to illustrate the prevalence split between T1D and T2D.size_opportunity
Open slide detailBeat · Visualization
37
Includes a scientific diagram illustrating the transition from hyperglycemia (beta-cell deficiency) to euglycemia (restored beta-cell mass) via AAV-mediated genpresent_solution
Open slide detailBeat · Visualization
38
The slide compares AAV8-PM (therapeutic) against AAV8-GFP (control) and an untreated control group.show_traction
Open slide detailBeat · Visualization
39
The slide uses a comparative analogy between mouse lifespan and human lifespan to suggest long-term efficacy.show_traction
Open slide detailBeat · Visualization
40
The slide uses a combination of a process description (left) and experimental data (line chart and bar chart) to validate the therapeutic hypothesis.present_solution
Open slide detailBeat · Visualization
41
NHP = Non-Human Primate. STZ likely refers to Streptozotocin, a compound used to induce diabetes in animal models.show_traction
42
ATTD likely refers to the Advanced Technologies & Treatments for Diabetes conference.show_traction
43
The data shows a significant improvement in glucose regulation post-therapy, closely tracking the normal NHP curve.analyze_data
44
IHC stands for Immunohistochemistry. The images show DAPI (blue), Insulin (cyan), and Glucagon (red) staining.present_solution
45
transition
49
The slide uses a grid layout to present five board members with their respective titles and professional summaries.other
50
The slide uses a column-based layout to track progress across different workstreams.plan_implementation
51
inspire_vision
52
front_matter
56
Includes bioluminescence imaging of tumor xenografts and bar charts quantifying Active T cells, MDSC, Active NK cells, and DC populations.show_traction
57
The slide highlights a triple combination therapy (Reqorsa + Carbo + Pembro) compared to standard of care.show_traction
58
The slide outlines the progression of a clinical trial from Phase 1 through Phase 2b.plan_implementation