Exscientia | Investor Day Presentation Deck | 90 slides

Exscientia · 2024-01
arc beats above · slides in the middle · loops below · scroll → 2 LOOPS
SETUP TENSION ANALYSIS EVIDENCE RESOLUTION APPENDIX
HOVER FOR DETAILS · CLICK A SLIDE FOR FULLSCREEN · STEP 5
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Slide inventory

90
every slide · same image gating as the playbook
01
Slide 1
Features a 3D molecular visualization.front_matter
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other
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The slide uses a split-screen layout to contrast internal R&D with external partnerships, unified by a central 'discovery programmes' stack.present_solution
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04
summarize
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05
Uses a before-after-framing structure to position the company's solution against industry-wide challenges.propose_solution
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06
summarize
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07
plan_implementation
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08
The slide uses a hub-and-spoke diagram centered on 'Precision Medicine' with six surrounding functional modules.present_solution
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09
present_solution
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10
The slide uses a horizontal bar chart structure to represent clinical development stages.present_solution
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11
compare_peers
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12
The table provides a clear view of liquidity and operational cash flow trends.analyze_data
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13
appendix
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14
The diagram uses a double-loop (infinity symbol) structure to represent iterative learning within a linear drug discovery pipeline.present_framework
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15
The slide uses a growth-oriented arrow diagram to illustrate technological maturity and value creation.present_solution
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16
The slide uses a horizontal timeline framework to map partnerships against target difficulty (GPCRs to novel targets).present_framework
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17
transition
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18
The slide uses a central vertical timeline/process flow with callouts to specific methodology components.present_solution
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19
transition
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20
Uses information theory to explain why 20 binary questions can narrow down a search space of 600,000 items.frame_problem
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21
The chart uses a series of iterative loop icons to represent the learning process.frame_problem
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22
The scatter plot highlights a specific cluster of compounds (labeled 1 and 2) that were selected by the active learning model despite being outside the typical illustrate_case
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23
The slide highlights technical infrastructure and R&D capabilities.establish_context
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24
The slide uses a process flow diagram to connect target criteria to computational optimization and final project telemetry.present_framework
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25
The diagram uses a hub-and-spoke style flow to show data integration, generative design, and iterative refinement.present_solution
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26
The slide features a 3D molecular model and a set of circular gauges representing various drug discovery metrics (potency, stability, toxicity, etc.).illustrate_case
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27
The slide highlights technical capabilities in computational chemistry/drug discovery.present_solution
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28
The slide uses a pyramid diagram to show a hierarchical process of drug discovery automation.present_framework
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29
transition
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30
The slide depicts a 'flywheel' or 'closed-loop' process architecture for automated scientific research.present_solution
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31
DMT cycle = design-make-test cyclepresent_solution
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32
The slide uses a combination of icons and a process diagram to illustrate the facility's capabilities.present_solution
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33
The slide uses an isometric technical illustration to depict a modular lab automation setup.present_solution
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34
The slide uses a before-after framing to contrast traditional chemical synthesis methods with the requirements of AI-driven design.present_framework
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35
The slide uses a process flow diagram at the top to show the workflow stages, followed by three specific hardware solutions.present_solution
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36
transition
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37
The slide uses a circular process flow to represent the R&D pipeline.present_solution
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38
The slide uses a process flow diagram to illustrate a specific patient journey.illustrate_case
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39
Kaplan-Meier survival curves comparing PFS1 (prior treatment) vs PFS2 (study treatment).analyze_data
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40
The slide uses a linear process flow to explain the study methodology.illustrate_case
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41
The slide uses a complex visual mapping to show drug response across two different biological models (patient samples vs cell lines).illustrate_case
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42
The slide uses a small multiples approach to show dose-response curves for individual patient samples, followed by a summary box plot on the right.analyze_data
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43
transition
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present_solution
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45
The slide features a molecular visualization of the inhibitor.transition
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46
The slide outlines a standard oncology clinical trial design (dose escalation followed by expansion).present_framework
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47
The slide uses a human anatomy diagram to map specific cancer types to their respective organs, providing a visual representation of the addressable market.size_opportunity
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48
The slide uses a biological pathway diagram to explain the mechanism of action and a honeycomb diagram to illustrate market breadth.size_opportunity
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49
The slide uses a three-column layout to define technical requirements for a pharmaceutical product.present_solution
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50
The table uses a color-coded heatmap to indicate performance against criteria (green=pass, yellow=minor deviation, red=major deviation).compare_peers
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51
The slide presents preclinical efficacy data for a CDK7 inhibitor ('617) in ovarian (OVCAR3) and triple-negative breast cancer (HCC70) models.analyze_data
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52
The waterfall plot shows sensitivity vs resistance. The right side shows a volcano plot for pathway analysis and a conceptual diagram for combination testing.analyze_data
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53
The slide uses a combination of a bar chart for single-agent sensitivity and a heatmap for combination synergy results.analyze_data
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54
The slide uses a Venn diagram to show gene overlap and line charts to show dose-response relationships for POLR2A and HNRNPDL.present_solution
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55
The slide features a 3D molecular visualization of the protein target.establish_context
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56
The slide uses a bar chart to demonstrate efficacy (reduction in PLN weight) at different doses of EXS4318 compared to a failed competitor drug.illustrate_case
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57
The slide uses a traffic-light color coding system to highlight the superior profile of EXS4318 compared to failed competitors.compare_peers
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58
The slide uses a process-flow layout with icons and bulleted lists for each stage.present_solution
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59
The slide features a 3D molecular model, likely representing the target protein or the drug-target complex.other
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60
The slide highlights the potential for '539 to address brain metastases in SCLC patients.size_opportunity
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61
The diagram illustrates the interaction network of LSD1 with various suppressors and activators.diagnose_problem
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62
The slide uses a biological process diagram to explain the mechanism of action for an LSD1 inhibitor.present_solution
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63
The slide uses a process flow diagram to explain the therapeutic strategy.present_solution
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present_solution
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65
The slide uses a three-column layout to define the strategic design requirements for a drug candidate.present_solution
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66
The slide uses a color-coded heatmap (green/yellow/red/grey) to indicate performance against criteria.compare_peers
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67
The slide uses a horizontal process flow to map out the stages from initiation to synthesis.plan_implementation
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68
The slide uses a Pareto front to illustrate the trade-off between CNS score and Potency, highlighting that the 'best' molecules are not always the most informatillustrate_case
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69
The slide uses two distinct chart types (dot plot and line chart) to demonstrate the safety profile of a reversible inhibitor compared to an irreversible one.analyze_data
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70
The slide uses box plots for aggregate data and line charts for individual patient sample responses, categorized by differentiation potential.analyze_data
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71
The chart compares single-agent activity (bar chart) against combination synergy (heatmap).analyze_data
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72
The slide includes two charts: a line chart showing tumour volume over time and a dot plot showing plasma pro-GRP concentration.analyze_data
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73
The slide uses a heatmap to show synergy scores across different cell lines and treatments, and line charts to demonstrate dose-response curves for specific comanalyze_data
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74
The heatmap displays AUC values for 16 patient samples across 3 treatments. Source: Okumura et al. ESMO, 2023.diagnose_problem
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summarize
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MIDD = Model-informed Drug Developmentsummarize
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77
The slide features a stylized molecular visualization, likely representing the MALT1 protein target.transition
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78
summarize
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The slide uses a biological pathway diagram to illustrate the mechanism of action.present_solution
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present_solution
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present_solution
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82
The slide uses a heatmap-style table to visualize performance against criteria, with a specific callout box highlighting the UGT1A1 row.compare_peers
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83
The slide outlines a multi-stage drug discovery pipeline integrating molecular dynamics (MD) and machine learning.present_solution
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84
The slide highlights the integration of molecular dynamics with binding site analysis (Hotspots) to improve drug design outcomes like permeability.present_solution
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85
Data shows tumor volume over time; asterisks indicate statistical significance.analyze_data
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86
The slide presents experimental data comparing efficacy in CLL cells vs T-cells.analyze_data
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87
The table uses color-coding (red/green) to highlight risk levels for UGT1A1 inhibition parameters.compare_peers
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summarize
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summarize
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This is a standard corporate contact/disclaimer slide often found at the end of an investor presentation.other
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