Kymera | Investor Presentation Deck | 46 slides

Kymera Therapeutics · 2023-12
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SETUP TENSION ANALYSIS EVIDENCE RESOLUTION APPENDIX
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Slide inventory

46
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01
Slide 1
Includes company logo and date.front_matter
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02
other
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03
summarize
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04
show_traction
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05
TPD stands for Targeted Protein Degradation. The slide uses a three-column framework to explain their competitive advantage.present_solution
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06
The slide uses a standard pharmaceutical pipeline table format.plan_implementation
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07
This is a stylistic section divider slide with an abstract background.transition
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08
The slide uses a biological pathway diagram to illustrate the mechanism of action for a drug candidate.present_solution
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09
Includes a mechanism of action diagram, a market data table, and a callout box on competitive limitations.size_opportunity
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10
Comparison of two distinct cohorts: Healthy Volunteers (SAD/MAD) vs. HS/AD Patient Cohort.show_traction
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11
Includes both a longitudinal line chart for IRAK4 degradation and a grouped bar chart with a supporting data table for cytokine inhibition.analyze_data
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12
Includes PK/PD correlation, blood IRAK4 levels, skin exposure, and skin lesion IRAK4 reduction data.show_traction
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13
The charts show log2(fold change) for individual patients. The footnote defines the log2(fold change) values in terms of percentage decrease.analyze_data
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14
Data compares 'All HS Patients' vs 'Moderate to Severe' subgroups across four metrics over 42 days.show_traction
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15
The slide includes a disclaimer that the comparison is not head-to-head and uses historical benchmarks.compare_peers
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16
Data presented as mean +/- S.E. of mean; N=7 patients.show_traction
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17
The slide includes a disclaimer regarding the non-head-to-head nature of the comparison.compare_peers
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18
The slide provides clinical safety data for the KT-474 drug candidate.analyze_data
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19
The slide outlines the status of a partnership with Sanofi and clinical trial timelines.show_traction
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20
Includes clinical trial identifiers and definitions of acronyms in the footer.analyze_data
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21
transition
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22
Includes a table of market data and a biological pathway diagram.present_solution
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23
Includes PK/PD data and efficacy metrics in multiple T-cell lymphoma models.show_traction
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24
Includes box plots for gene expression and a tumor volume growth curve over time.show_traction
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25
The slide uses a process flow diagram to illustrate the transition from dose escalation (DL1-DLx) to expansion cohorts for specific indications.plan_implementation
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26
transition
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27
Data cut-off: 18 October 2023. Includes breakdown by age, sex, ECOG status, prior therapy, and tumor type.analyze_data
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28
Clinical trial safety data summary.summarize
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29
The table tracks clinical trial outcomes (PR: Partial Response, SD: Stable Disease, PD: Progressive Disease) for a drug candidate.show_traction
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30
Includes both tabular summary of dose-level degradation and visual histology/bar chart evidence of tumor reduction.show_traction
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31
Includes longitudinal line charts for blood mRNA levels and a bar chart/enrichment plot for tumor response.show_traction
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32
The slide uses a split-layout: left side for clinical data results, right side for strategic opportunity/implications.show_traction
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33
transition
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34
Includes a waterfall plot showing p53WT cell dependency on MDM2 and a biological process diagram of the MDM2-p53 feedback loop.present_solution
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35
Includes three dose-response curves and a comparative table of clinical stage and potency metrics.compare_peers
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36
Comparison of protein levels and tumor volume over time across multiple dosing regimens.show_traction
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37
The slide uses a standard clinical trial dose-escalation diagram and a demographic table.analyze_data
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38
The slide uses a biological mechanism diagram on the left and clinical data (table and line chart) on the right to validate the drug's mechanism of action.show_traction
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39
The chart is a swimmer plot, a standard tool in oncology clinical trials to visualize duration of response.show_traction
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40
Clinical trial safety reporting slide.show_traction
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41
The slide uses a split-layout comparing technical mechanism/data (left) with strategic opportunity (right).show_traction
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42
plan_implementation
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43
This is a standard closing slide for an investor presentation.state_next_steps
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44
appendix
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45
The table displays patient counts and percentages for specific adverse events categorized by dose level (DL1-DL5) and overall.analyze_data
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46
Includes both a summary table of response categories and a swimmer plot for treatment duration.show_traction
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