Chimerix | Investor Presentation Deck | 43 slides

Chimerix · 2023-08
arc beats above · slides in the middle · loops below · scroll → 2 LOOPS
SETUP TENSION ANALYSIS EVIDENCE RESOLUTION APPENDIX
HOVER FOR DETAILS · CLICK A SLIDE FOR FULLSCREEN · STEP 2
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Slide inventory

43
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01
Slide 1
front_matter
03
summarize
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The slide uses a Gantt-style chart to represent drug development progress.plan_implementation
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transition
06
Includes a Kaplan-Meier survival curve, an anatomical illustration of tumor locations, and a comparative table of clinical outcomes.frame_problem
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07
BICR = Blinded Independent Central Review; RANO = Response Assessment in Neuro-Oncology; HGG = High-Grade Glioma; LGG = Low-Grade Glioma; SAEs = Serious Adverseshow_traction
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08
The slide details specific inclusion/exclusion criteria, including age, mutation status, prior therapy, and washout periods.plan_implementation
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09
The slide highlights clinical trial results with specific response and disease control rates for two different RANO criteria.show_traction
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10
The chart is a waterfall plot (often called a swimmer plot or spider plot in oncology, though technically a waterfall).show_traction
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11
The chart is a waterfall plot showing Best % Change in SPD from Baseline. The legend indicates PS scores (060-100).analyze_data
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12
The chart is a classic 'spider plot' used in oncology clinical trials to visualize individual patient tumor burden changes over time.show_traction
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13
Data presented in two tables comparing healthy adult dose escalation vs glioma patient safety profiles.analyze_data
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14
The slide highlights the correlation between RANO response criteria and improved clinical outcomes in H3 K27M-mutant DMG patients.show_traction
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15
The table uses a color-coded heatmap to highlight favorable (green) vs unfavorable (pink) characteristics of clinical trial data.compare_peers
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16
transition
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17
The slide uses a process flow diagram to illustrate the trial structure.plan_implementation
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18
summarize
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19
The slide details specific event counts and target hazard ratios for OS and PFS endpoints.analyze_data
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20
The chart shows a dose-response curve where longer incubation times (48+ hours) result in higher efficacy (lower cell viability) at lower concentrations comparepresent_solution
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21
transition
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22
The slide uses a medical illustration of the brain to map patient counts and positivity rates to specific anatomical regions.size_opportunity
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23
size_opportunity
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24
Slide 24 of the deck.establish_context
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25
Waterfall plot displays individual patient responses; PD indicates Progressive Disease threshold.show_traction
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26
transition
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27
Includes a detailed biological pathway diagram showing mitochondrial and membrane-level interactions.present_solution
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28
Includes citations to Chi et al. (2017) and Piccardo et al. (2019).present_solution
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29
Includes a mechanism illustration, a bar chart of H3K27me3 levels, a Kaplan-Meier survival curve, and a dot plot of patient tumor data.show_traction
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30
transition
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31
Includes molecular structure and protein target visualizations.present_solution
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32
The slide uses a central human anatomical illustration to bridge the two distinct types of cancer models presented.show_traction
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33
Includes logos for NIH and Pacific Pediatric Neuro-Oncology Consortium.show_traction
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34
Includes an in vitro cell viability dose-response curve and a pharmacokinetic (PK) model showing plasma concentration over time.present_solution
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35
The chart illustrates dose levels 1-11 with checkmarks indicating completed levels and a clear distinction between weekly and 3-day dosing regimens.show_traction
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36
Uses a visual icon array to represent survival rates.size_opportunity
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37
transition
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38
The slide uses a visual comparison of tumor burden in mice to demonstrate efficacy.present_solution
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39
The chart shows a clear dose-response/timing-response relationship where earlier treatment leads to lower viral titers.show_traction
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40
transition
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41
analyze_data
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42
show_traction
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43
front_matter
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