Exscientia | Investor Presentation Deck | 73 slides

Exscientia · 2023-07
arc beats above · slides in the middle · loops below · scroll → 2 LOOPS
SETUP TENSION ANALYSIS EVIDENCE RESOLUTION APPENDIX
HOVER FOR DETAILS · CLICK A SLIDE FOR FULLSCREEN · STEP 5
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Slide inventory

73
every slide · same image gating as the playbook
01
Slide 1
Includes company logo and date.front_matter
03
The slide uses a grid of big numbers to summarize key business metrics.summarize
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plan_implementation
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frame_problem
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06
The diagram uses a hub-and-spoke model centered on a human silhouette representing precision medicine.present_solution
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The chart uses a horizontal bar format to represent development stages.plan_implementation
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The table highlights the company's precision medicine approach to drug development.present_solution
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The diagram uses a concentric circle structure to represent layers of value.present_solution
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The slide uses a stepped arrow diagram to represent progress over time, categorized into three phases of target difficulty.plan_implementation
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The slide uses a 3x2 grid layout to present quantitative achievements.show_traction
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Includes footnote regarding fixed term bank deposits and share count.analyze_data
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transition
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The diagram uses a complex flow-chart style with a central infinity loop representing the 'learning' aspect of the AI architecture.present_solution
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The slide uses a circular process flow to represent a proprietary R&D pipeline.present_solution
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The slide uses a process flow to illustrate a specific patient success story.show_traction
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17
Includes Kaplan-Meier survival curves and a clinical decision pathway diagram.show_traction
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18
The slide uses a horizontal layout with four circular imagery icons representing different technical capabilities, each supported by a list of specific featurespresent_solution
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The slide uses a fan-like layout to show the integration of different technological approaches.present_solution
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The slide uses a circular process diagram to illustrate the integration of various data sources into the Centaur Biologist engine.present_solution
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21
The slide uses a hierarchical clustering heatmap to demonstrate patient-specific drug responses.frame_problem
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22
The slide uses a process flow diagram to show how target criteria are translated into code-based optimization and then visualized as project telemetry.present_solution
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The diagram uses a hub-and-spoke style flow to show data integration, model selection, generative design, and an iterative experimental feedback loop.present_solution
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24
The slide features a 3D molecular visualization and a dashboard of performance metrics (Potency, Selectivity, etc.) typical of computational drug discovery softpresent_solution
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The scatter plot shows a Pareto-like frontier of compounds, with the AI selecting specific points (labeled 1 and 2) that are not necessarily the highest-performpresent_solution
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The slide uses a small multiples approach to show dose-response curves across multiple patient samples, grouped by sensitivity.analyze_data
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transition
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present_solution
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The slide uses a stylized molecular or particle-based visual representation, likely related to the drug's mechanism of action.show_traction
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The slide outlines a standard oncology clinical trial design (Phase 1/2) with a specific focus on biomarker-driven patient selection.plan_implementation
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The slide displays a heatmap of 43 patient samples showing ABS scores, signature scores, and cancer diagnoses.present_solution
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Includes specific p-values for Blood Mononuclear Cells and references to Fong et al (2020) and Vladimer et al (2022).analyze_data
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The slide uses a combination of donut charts for sample sizes and bar charts for statistical significance, followed by scatter plots to visualize the inverse coanalyze_data
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The slide presents two line charts with box plots showing dose-response relationships in lung cancer samples.analyze_data
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35
The slide presents two key charts: a scatter plot showing the correlation between plasma exposure and target inhibition, and a line chart showing plasma concentshow_traction
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The slide uses a stylized molecular visualization as a background element.show_traction
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The slide outlines a standard oncology clinical trial design (Phase 1/2) with a transition point at RP2D (Recommended Phase 2 Dose).plan_implementation
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Includes a biological pathway diagram and a honeycomb diagram for indications.size_opportunity
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The slide uses a three-column layout to define the target product profile (TPP) requirements for a CDK7 inhibitor.present_solution
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The table uses a color-coded heatmap (green/yellow/red) to indicate performance against criteria.compare_peers
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Data source: Besnard et al, AACR (2022).show_traction
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The slide uses a small multiples approach to show dose-response curves across 10 patient samples, then aggregates them into two groups to highlight differentialanalyze_data
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The right chart is a waterfall plot showing drug response scores across 53 patient samples, categorized by tumor type and responder status.present_solution
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The slide shows a hierarchical clustering heatmap of gene expression alongside bar charts comparing experimental vs predicted tDRS values for 30 sample patientsanalyze_data
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The slide uses a stylized abstract graphic, likely representing molecular structures or data points.show_traction
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TPP stands for Target Product Profile.present_solution
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The slide uses a traffic-light color coding system (green/yellow/red) to visualize performance metrics.compare_peers
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The slide uses a process-flow layout to describe the company's proprietary drug discovery methodology.present_solution
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49
The slide uses a high-impact visual of a protein-ligand interaction to establish the product's identity.present_solution
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present_solution
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Includes two distinct biological diagrams/illustrations and citations for scientific literature.present_solution
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52
The slide uses a three-column layout to define the technical requirements for the drug candidate.present_solution
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The slide uses a color-coded heatmap (green/yellow/red/grey) to visualize performance against target product profile (TPP) criteria.compare_peers
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The slide uses a linear process flow to describe a drug discovery pipeline.present_solution
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The chart illustrates a Pareto front analysis in drug discovery, highlighting the selection of compounds that are not necessarily 'optimal' by standard metrics present_solution
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Includes statistical significance markers (*) and safety observation regarding body weight.show_traction
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The slide uses two distinct chart types (dot plot and line chart) to contrast the safety profiles of reversible vs irreversible LSD1 inhibitors.present_solution
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The chart shows tumour volume over time for various dosing regimens, with statistical significance indicated by ****.show_traction
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present_solution
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Includes a definition for MIDD at the bottom left.summarize
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The background features a 3D molecular visualization, likely representing the MALT1 protein structure.present_solution
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present_solution
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frame_problem
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present_solution
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present_solution
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The slide uses a color-coded matrix to highlight that competitors fail on UGT1A1 inhibition, while EXS73565 succeeds.compare_peers
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67
The slide outlines a multi-stage pipeline: Initiate, Analyse, Evolve, 2D Models, 3D Models, and Active Learning.present_solution
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68
The slide highlights the technical methodology behind a specific drug candidate ('565) using molecular dynamics.present_solution
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69
The chart shows dose-dependent tumour volume reduction over time compared to vehicle control.show_traction
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70
The chart shows tumor volume over time (D20-D30) for various treatment groups, highlighting the superior performance of the combination therapy.present_solution
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show_traction
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The slide uses a split-layout with status updates on the left and program highlights on the right.summarize
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This is a standard corporate contact/disclaimer slide.other
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