Comera | Investor Presentation Deck | 22 slides

The slide uses a conceptual graph showing the relationship between concentration, PPI, and viscosity, alongside a molecular diagram showing protein aggregation.frame_problem

Open slide detailBeat · Problem Statement

The slide illustrates the mechanism of action for the SQore platform, showing the transition from high-viscosity, high-PPI protein clusters to low-viscosity, lopresent_solution

Open slide detailBeat · Proposed Solution

The slide uses a funnel diagram to represent the development process and a circular flow diagram for biophysical studies.present_framework

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The slide illustrates a computational workflow for drug formulation optimization.present_solution

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The slide outlines a three-step computational process: identifying interaction sites, screening a library (SQore), and ranking results.present_solution

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The slide uses visual comparisons of protein structures and corresponding RMSD and Hydrogen Bond plots to demonstrate the utility of MD simulations.analyze_data

Open slide detailBeat · Methodology

The slide illustrates a dual-track approach (biophysical studies vs. computational modeling) feeding into an excipient selection matrix.present_framework

Open slide detailBeat · Methodology

Shows CD thermal melt data for Nivolumab, Trastuzumab, Pembrolizumab, and Ustekinumab.analyze_data

Open slide detailBeat · Key Takeaways

Data shows percentage of monomer remaining for different stabilizer formulations compared to control.analyze_data

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Data presented as bar charts showing particle counts per ml across different size ranges.analyze_data

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Shows sensorgrams for different concentrations of stabilizers.analyze_data

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transition

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The DLS screen shows hydrodynamic radius (Rh) over time for various buffers; the accelerated stress screen compares 0-week vs 2-week stability across four buffeanalyze_data

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The slide displays three distinct charts: two BLI sensorgrams (top left and bottom left) and one viscosity vs concentration scatter plot (right).analyze_data

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The slide demonstrates a progression from initial screening (DLS) to final stability assessment (monomer loss) to justify the selection of specific excipient coanalyze_data

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Includes a scatter plot, bar chart, line chart, and summary table comparing different stabilizer mixtures.analyze_data

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Includes a bar chart of DOE samples, a linear regression plot of pH vs monomer, and a heatmap of sugar vs pH.analyze_data