MindMed | Results Presentation Deck | 40 slides

MindMed · 2022-05
arc beats above · slides in the middle · loops below · scroll → 3 LOOPS
SETUP TENSION ANALYSIS EVIDENCE RESOLUTION APPENDIX
HOVER FOR DETAILS · CLICK A SLIDE FOR FULLSCREEN · STEP 2
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Slide inventory

40
every slide · same image gating as the playbook
01
Slide 1
front_matter
03
front_matter
04
summarize
05
The slide uses a 3x3 matrix structure to categorize drug development strategy by generation (Classic, 2nd Gen/Optimized, 3rd Gen/NCEs).present_framework
06
The chart uses horizontal bars to indicate the current development stage of various drug candidates.plan_implementation
07
The slide uses a Gantt-style layout to map clinical trial phases against a timeline.plan_implementation
09
introduce_nominees
10
Includes institutional branding for Johns Hopkins Bayview and Maryland Opioid Research (MOR).front_matter
11
The chart illustrates the escalating mortality rates associated with different categories of drugs over time.analyze_data
Open slide detailBeat · ProblemLoop · Cost Of Inaction
12
The slide uses a shaded area for acute withdrawal and a dashed line for protracted withdrawal, mapped against time intervals for short-acting and long-acting oppresent_framework
Open slide detailBeat · ProblemLoop · Cost Of Inaction
13
The slide uses a simple process-flow diagram to categorize treatment options.present_framework
Open slide detailBeat · ProblemLoop · Cost Of Inaction
14
The chart illustrates the divergence between OUD prevalence and treatment capacity over time (2003-2012).expose_gap
Open slide detailBeat · ProblemLoop · Cost Of Inaction
15
The chart illustrates a clear divergence between maintenance and supervised withdrawal regarding the use of opioid agonists.diagnose_problem
Open slide detailBeat · AgitateLoop · Cost Of Inaction
16
Includes a citation of a specific academic paper on non-opioid neurotransmitter systems.present_solution
Open slide detailBeat · AgitateLoop · Cost Of Inaction
17
The slide introduces a chemical compound (18-MC) and its relationship to ibogaine, highlighting a distinct mechanism of action and potential safety benefits.establish_context
Open slide detailBeat · SolutionLoop · Trojan Horse
18
Source: Glick & Maisonneuve, 2000. The slide uses two different chart types (line and bar) to demonstrate the same pharmacological effect.analyze_data
Open slide detailBeat · SolutionLoop · Trojan Horse
19
The slide uses a bar chart to demonstrate the specificity of 18-MC compared to Ibogaine in a pharmacological study.summarize
Open slide detailBeat · SolutionLoop · Trojan Horse
20
Slide contains two distinct charts labeled A and B, referencing specific research papers.analyze_data
Open slide detailBeat · SolutionLoop · Trojan Horse
21
The slide displays 7 distinct bar charts representing different withdrawal symptoms (Weight Loss, Wet-Dog Shakes, Flinching, Grooming, Teeth Chattering, Buryinganalyze_data
Open slide detailBeat · SolutionLoop · Trojan Horse
22
The chart highlights specific withdrawal symptoms (Wet-Dog Shakes, Teeth Chattering, Burying, Diarrhea) that show statistically significant reductions with 18-Manalyze_data
Open slide detailBeat · SolutionLoop · Trojan Horse
23
compare_peers
Open slide detailBeat · SolutionLoop · Trojan Horse
24
The slide uses a 'So Why Now?' framing to justify the relevance of the topic.establish_context
Open slide detailBeat · SolutionLoop · Trojan Horse
25
The table uses color coding (yellow for TBD/preclinical, green for established/favorable) to highlight the developmental status of 18-MC versus the established compare_peers
Open slide detailBeat · SolutionLoop · Trojan Horse
26
summarize
Open slide detailBeat · Solution
27
The slide outlines a timeline of clinical trial events for the drug candidate MM-110.plan_implementation
Open slide detailBeat · Solution
28
The slide uses a combination of a longitudinal bar/line chart and key metrics to quantify the problem.diagnose_problem
Open slide detailBeat · Solution
29
The slide uses a line chart metaphor to represent patient state/cravings over time, highlighting the intervention point of MM-110.present_solution
Open slide detailBeat · Solution
30
The slide presents preclinical efficacy data for MM-110 using bar and line charts.analyze_data
Open slide detailBeat · Solution
31
The slide presents data from Rho & Glick (1998) showing dose-dependent reduction in withdrawal behaviors.analyze_data
Open slide detailBeat · Solution
32
The chart compares saline vs. Methoxycoronaridine (MM-110) across 6 time points (Base, Day 1, 2, 3, 6, 7).analyze_data
Open slide detailBeat · Solution
33
summarize
Open slide detailBeat · Solution
34
SAD = Single Ascending Dose; MAD = Multiple Ascending Dose. Data shows n (%) of participants experiencing safety events.analyze_data
Open slide detailBeat · Evidence & ProofLoop · Hypothesis Test
35
Data presented as n (%). SOC and PT assigned using MedDRA version 23.0.analyze_data
Open slide detailBeat · Evidence & ProofLoop · Hypothesis Test
36
SAD = Single Ascending Dose, MAD = Multiple Ascending Dose. Data presented as n (%).analyze_data
Open slide detailBeat · Evidence & ProofLoop · Hypothesis Test
37
Data represents cohorts 12 and 15 of MMED003 study.analyze_data
Open slide detailBeat · Evidence & ProofLoop · Hypothesis Test
38
Data shown are means, n=5 (Cohort 14 of Study MMED003) using validated LC-MS/MS assay for zolunicant.analyze_data
Open slide detailBeat · Impact & Next Steps
39
The slide outlines a sequential study design where Part A informs the design of Part B.present_framework
Open slide detailBeat · Impact & Next Steps
40
summarize
Open slide detailBeat · Impact & Next Steps