Graphite Bio | IPO Presentation Deck | 50 slides

Graphite Bio · 2021-06
arc beats above · slides in the middle · loops below · scroll → 4 LOOPS
SETUP TENSION ANALYSIS EVIDENCE RESOLUTION APPENDIX
HOVER FOR DETAILS · CLICK A SLIDE FOR FULLSCREEN · STEP 2
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Deck intelligence map

7
coverage by narrative range · generated from this deck JSON

Slide inventory

50
every slide · same image gating as the playbook
01
Slide 1
front_matter
Open slide detailBeat · Setup
02
other
Open slide detailBeat · Setup
03
summarize
Open slide detailBeat · Setup
04
The slide uses a visual metaphor of DNA editing to frame the company's mission.inspire_vision
Open slide detailBeat · HookLoop · Golden Circle
05
The slide uses a photo of Oliver Smithies and a screenshot of a scientific publication to establish credibility and historical foundation.establish_context
Open slide detailBeat · HookLoop · Golden Circle
06
The slide uses a combination of a personal photo (Matt Porteus) and a scientific citation to establish credibility and the 'why now' or 'scientific foundation' inspire_vision
Open slide detailLoop · Aha Moment
07
The slide uses a scientific diagram of the Cas9 mechanism alongside a citation of the seminal 2013 Science paper by Mali et al.establish_context
Open slide detailLoop · Aha Moment
08
Uses a software UI metaphor ('Find and Replace') to explain biological gene editing.present_solution
Open slide detailLoop · Aha Moment
09
The slide uses a split-screen comparison layout to contrast two distinct therapeutic modalities.present_solution
Open slide detailLoop · Aha Moment
10
Slide 10 of an investor presentation.summarize
11
The slide uses a grid layout to present headshots, names, titles, and company logos for 8 individuals.other
12
The slide uses a hexagonal motif for board member headshots.cite_precedent
13
The slide uses a linear process flow to illustrate strategic expansion from specific genetic diseases to broader therapeutic areas.plan_implementation
14
The chart uses a horizontal bar format to represent progress through clinical development stages.plan_implementation
15
transition
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The slide uses a contrast-pair framework to highlight the superiority of their specific technical approach over the standard alternative.present_solution
Open slide detailBeat · Solution & Approach
17
The slide uses a process-oriented framework to explain the technical solution.present_solution
Open slide detailBeat · Solution & Approach
18
The chart shows a significant jump in beta-globin correction percentage with the optimized Graphite Bio approach.show_traction
Open slide detailBeat · Solution & Approach
19
The slide uses a visual comparison framework to highlight the advantages of the company's proprietary technology.compare_peers
Open slide detailBeat · Solution & Approach
20
The slide uses a process flow diagram to explain the mechanism of action for the company's gene editing platform.present_solution
Open slide detailBeat · Solution & Approach
21
The slide uses a hub-and-spoke diagram to visualize the versatility of the platform.present_solution
22
The slide uses a three-column structure to explain the biological basis, clinical proof-of-concept, and the company's specific therapeutic approach.present_solution
23
The slide uses a high-contrast, textured background with a clean white overlay for text, typical of a section transition in a biotech pitch deck.transition
24
Uses a before-after-bridge framing structure.frame_problem
Open slide detailBeat · Problem (Identify pain)Loop · Cost Of Inaction
25
The slide uses a scientific citation to validate the prevalence of the sickle trait.establish_context
Open slide detailBeat · Problem (Identify pain)Loop · Cost Of Inaction
26
Uses a 'Find and Replace' software metaphor to explain CRISPR-based gene editing.present_solution
27
Uses a three-part visual comparison to illustrate the disease state, the curative threshold, and the therapeutic solution.present_solution
Open slide detailBeat · Evidence
28
The slide uses a process flow diagram to link gene editing outcomes to clinical outcomes.present_solution
Open slide detailBeat · Evidence
29
The slide uses a three-part process flow (Correct, Measure ex vivo, Measure in vivo) with corresponding data charts for each stage.show_traction
Open slide detailBeat · Evidence
30
The slide uses a two-part process flow (correction then measurement) to validate the therapeutic approach.show_traction
Open slide detailBeat · Satisfaction
31
The slide uses a before-and-after visual comparison to validate the efficacy of the gene correction technology.present_solution
Open slide detailBeat · Satisfaction
32
The slide uses a high-authority testimonial to frame the company's mission as the 'ultimate' solution.inspire_vision
33
The slide uses a visual comparison framework to contrast the company's direct gene correction method with indirect methods like transgenic addition, CRISPR HbF compare_peers
34
Includes a scientific chart showing oxygen dissociation curves for fetal vs adult hemoglobin.present_solution
35
Uses a funnel-like decomposition of the patient population.size_opportunity
36
Uses a visual funnel/segmentation approach to show how the total patient population is filtered down to the target segment for the new therapy.size_opportunity
37
SMC likely stands for Safety Monitoring Committee.plan_implementation
38
The slide uses a linear process flow (timeline-like) to illustrate strategic evolution.plan_implementation
39
The slide uses a three-column layout to explain the problem, the mechanism of action, and the future potential/conditioning strategy.present_solution
40
The slide uses a bar chart to establish the clinical threshold for success in different disease areas, framing the company's antibody conditioning strategy.present_framework
41
The slide uses a comparative framework to show how different genetic loci can be targeted for different therapeutic outcomes.present_solution
42
The slide uses a process flow to explain the mechanism of action for a gene therapy platform.present_solution
43
The chart illustrates the addressable market size for different genetic conditions targeted by the company's platform.size_opportunity
44
The slide uses a circular/pathway diagram to illustrate strategic evolution.plan_implementation
45
The slide uses a grid layout to categorize academic citations by therapeutic area.show_traction
46
The central hub is a circular segmented graphic representing the integration process, with spokes connecting to specific cell types and disease areas.present_solution
47
state_next_steps
Open slide detailBeat · Closing AskLoop · Quick Win Big Bet
48
plan_implementation
Open slide detailBeat · Closing AskLoop · Quick Win Big Bet
49
The slide uses a high-impact visual metaphor for gene editing to anchor the company's mission.inspire_vision
Open slide detailBeat · Closing AskLoop · Quick Win Big Bet
50
state_next_steps
Open slide detailBeat · Closing AskLoop · Quick Win Big Bet