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319,975 slides

319,974 are described (100%), so the treemap can explain the corpus instead of just counting files.

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319,975
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319,974
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Slide collection

172,081-172,140 of 319,975

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38
Data presented at Kymera R&D Day 2021. LLOQ = Lower Limit of Quantitation.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
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IRAK4 is stained red, DAPI is blue, and panCK (pan cytokeratin) is green.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
40
Data shows dose-dependent reduction in cytokine levels compared to placebo, correlated with IRAK4 degradation percentages.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
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The table details specific adverse events (Headache, Palpitations, Nausea) with subject counts, severity, and cohort distribution.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
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SAD = Single Ascending Dose; MAD = Multiple Ascending Dose; LLOQ = Lower Limit of Quantitation; HS = Hidradenitis Suppurativa; AD = Atopic Dermatitis.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
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Kymera | Investor Day Presentation Deck | 105 slidesKymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
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Kymera | Investor Day Presentation Deck | 105 slidesKymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
45
The slide uses a hierarchical structure where three core pillars feed into an 'Expanding capabilities' foundation.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
46
The slide uses a grid layout to map drug assets against therapeutic areas (Dermatology, Respiratory, GI, Rheumatology, Hematology, Neurology, Oncology) and color-coded mechanisms of action.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
47
The slide uses a process flow diagram to map biological signaling pathways from upstream initiation to downstream clinical manifestations.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
48
Includes a biological pathway diagram and three charts demonstrating efficacy in inhibiting pNFkB, cytokines, and IRAK4 degradation.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
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Kymera | Investor Day Presentation Deck | 105 slidesKymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
50
The slide illustrates a biological pathway diagram showing how IRAKiMiDs degrade both IRAK4 and IMiD substrates to inhibit proliferation and survival in cancer cells.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
51
The slide uses a structured layout to contrast patient numbers with clinical disease characteristics.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
52
Includes potency metrics (DC50, EC50) and dose-response curves for multiple cell lines.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
53
Includes tumor volume growth curves and PK/PD degradation profiles.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
54
The slide demonstrates synergistic efficacy of KT-413 across three different combination therapies.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
55
The diagram illustrates a multi-arm clinical trial design with dose escalation (DL1, DL2, DLx) leading to MTD/RP2D expansion cohorts for various indications, including combination therapy arms.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
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The diagram maps clinical trial inputs (left) to regulatory outcomes (right).Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
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Kymera | Investor Day Presentation Deck | 105 slidesKymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
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Kymera | Investor Day Presentation Deck | 105 slidesKymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
59
The slide uses a biological pathway diagram to explain the mechanism of action for a therapeutic target.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
60
The slide uses a central column to highlight patient numbers (US and ROW) for four specific disease indications, with clinical rationale on the right.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
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The chart is a volcano plot, a common visualization in proteomics to show statistical significance vs. fold change.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
62
The slide displays two line charts showing tumor volume over time for different dosing regimens.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
63
Includes box plots for gene expression and tumor volume growth curves, plus a Kaplan-Meier survival curve.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
64
The slide uses a process flow diagram to show the progression from initial dose levels (DL1, DL2, DLx) to expansion cohorts for various cancer types and combination therapies.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
65
The slide uses a process-flow diagram to map clinical trial phases to regulatory approval outcomes.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
66
Kymera | Investor Day Presentation Deck | 105 slidesKymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
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Kymera | Investor Day Presentation Deck | 105 slidesKymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
68
The diagram illustrates a complex signaling loop involving STAT3, cytokines, and various cell types (leukocytes, endothelial, stromal) leading to disease states.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
69
The slide uses a structured table-like layout to map diseases to patient impact metrics and scientific evidence.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
70
The slide displays bar charts for fibrosis and bone growth, and line charts for clinical scores in arthritis and EAE models, alongside a summary table for the EAE model.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
71
Kymera | Investor Day Presentation Deck | 105 slidesKymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
72
Kymera | Investor Day Presentation Deck | 105 slidesKymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
73
The slide uses a three-column structure to define the selection process: Philosophy, Target Types, and Therapeutic Profile.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
74
The slide uses a timeline-based grid to map specific assets (KT-474, KT-413, KT-253, KT-333) and future target pipelines against years 2021-2026.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
75
Kymera | Investor Day Presentation Deck | 105 slidesKymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
76
The chart is a waterfall plot showing dependency scores across various cell lines, illustrating that p53-wildtype cells are highly dependent on MDM2.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations Loop · Cost Of Inaction1 hit
77
The slide uses a biological pathway diagram to contrast two therapeutic modalities (inhibitor vs. degrader) in the context of p53 regulation.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations Loop · Cost Of Inaction1 hit
78
The slide uses a three-part process flow (degradation -> stabilization -> killing) supported by dose-response curves and a summary table.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations Loop · Cost Of Inaction1 hit
79
The slide uses a biological mechanism diagram to explain the experimental results shown in the Western blots.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations Loop · Cost Of Inaction1 hit
80
Shows that KT-253 (degrader) induces apoptosis even after short exposure, whereas DS-3032 (SMI) does not.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations Loop · Cost Of Inaction1 hit
81
The slide compares tumor volume over time against biomarker expression levels (p53, p21, PUMA) following KT-253 administration.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations Loop · Cost Of Inaction1 hit
82
The left chart is a waterfall plot showing CRISPR sensitivity scores; the right chart is a dose-response curve comparing KT-253 and DS-3032.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations Loop · Cost Of Inaction1 hit
83
Uses a Venn diagram to segment potential patient populations for MDM2 degradation therapy.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations Loop · Cost Of Inaction1 hit
84
Kymera | Investor Day Presentation Deck | 105 slidesKymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations Loop · Cost Of Inaction1 hit
85
Kymera | Investor Day Presentation Deck | 105 slidesKymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
86
The slide uses a visual metaphor of a 'wedge' expanding the druggable portion of the human proteome.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
87
Uses a three-column structure to categorize target classes and corresponding TPD solutions (Heterobifunctional Degraders, Molecular Glues).Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
88
The slide uses a list-based structure to detail technical capabilities, with a sidebar legend explaining target types.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
89
The chart uses dot size to represent abundance and color to represent different ligases/targets across tissue types.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
90
The slide uses a dot plot to show expression profiles and molecular modeling to show ternary complex formation.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
91
Shows Western blot data for E3 ligase expression and dose-response curves for POI degradation in cancer vs blood cells, plus in vivo viability comparison.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
92
The slide uses a horizontal process-like layout to categorize different scientific screening techniques.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
93
The slide uses a process flow diagram for the fragment-based optimization and a heatmap for the covalent ligand screening.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
94
The table demonstrates a clear progression in optimization from Degrader 1 to Degrader 4, particularly in oral bioavailability (F%) across species.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
95
The slide uses a process flow: MoA description -> Preclinical data (dog) -> Human prediction model.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
96
The slide uses a visual comparison between 'Heterobifunctional Degraders' and 'Molecular Glues' to frame the technical approach.Kymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit
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Kymera | Investor Day Presentation Deck | 105 slidesKymera | Investor Day Presentation Deck | 105 slides · Kymera
Conference presentation Investor relations 1 hit