{
  "docId": "019de517-75a1-7387-968b-d0dc513bf421",
  "docSlug": "e930bfcc8684afb6f5a4dd5442b5166d",
  "documentTitle": "Ocuphire Pharma | Investor Presentation Deck | 42 slides",
  "authorId": "ocuphire-pharma",
  "authorName": "Ocuphire Pharma",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2023-11-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 37,
  "pageCount": 42,
  "prevPage": 36,
  "nextPage": 38,
  "slideType": "preclinical_data",
  "function": "present_solution",
  "density": "overcrowded",
  "nDataPoints": 10,
  "notes": null,
  "elementsJson": null,
  "metadataConfidence": 0.9,
  "imagePath": null,
  "slideHref": "/slides/019de517-75a1-7387-968b-d0dc513bf421/37",
  "deckHref": "/decks/019de517-75a1-7387-968b-d0dc513bf421",
  "deckJsonHref": "/decks/019de517-75a1-7387-968b-d0dc513bf421.json",
  "deckAnchorHref": "/decks/019de517-75a1-7387-968b-d0dc513bf421#slide-37",
  "components": [
    {
      "bbox": {
        "h": 0.037,
        "w": 0.075,
        "x": 0.038,
        "y": 0.945
      },
      "kind": "image",
      "text": "Ocuphire",
      "attrs": {},
      "subkind": "logo",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "a655df07-a974-46ea-8fd1-ea06931c1427",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.469,
        "w": 0.401,
        "x": 0.087,
        "y": 0.183
      },
      "kind": "image",
      "text": "L-CNV Mouse Retina Model APX3330 Gavage OCT Lesion Volume",
      "attrs": {},
      "subkind": "screenshot",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "03b01a5c-f9c5-4357-b3c3-f2d607cbe6a4",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.469,
        "w": 0.39,
        "x": 0.567,
        "y": 0.183
      },
      "kind": "image",
      "text": "L-CNV Mouse Retina Model *EYLEA Anti-VEGF164",
      "attrs": {},
      "subkind": "screenshot",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "14409f1a-f378-4ffc-b239-ae37947824c1",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.02,
        "w": 0.828,
        "x": 0.07,
        "y": 0.764
      },
      "kind": "list",
      "text": "Efficacy was also seen after single intravitreal injection of 20μM APX3330 in mouse L-CNV model**",
      "attrs": {},
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "1396ddda-0c94-4233-8bb6-5aae8f01d01a",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.04,
        "w": 0.828,
        "x": 0.07,
        "y": 0.79
      },
      "kind": "list",
      "text": "Efficacy was also seen after dosing intraperitoneal injection of 50 mg/kg twice daily, 5 days on/2 days off, for 2 weeks in mouse L-CNV model***",
      "attrs": {},
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "676f9325-40cf-41af-a967-7766886a3220",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.02,
        "w": 0.828,
        "x": 0.07,
        "y": 0.84
      },
      "kind": "list",
      "text": "Efficacy was also seen after single intravitreal injection of 20µM APX3330 in Vldlr-/-mice model****",
      "attrs": {},
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "d24dd37c-56a4-45fa-842b-cbb50d558989",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.015,
        "w": 0.018,
        "x": 0.953,
        "y": 0.962
      },
      "kind": "other",
      "text": "37",
      "attrs": {},
      "subkind": "unclassified",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "d08ff216-e718-4b85-bf9f-d877efe7fc0f",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.011,
        "w": 0.66,
        "x": 0.127,
        "y": 0.96
      },
      "kind": "source-note",
      "text": "*Published data on EYLEA. This study was performed independently from APX3330 study and is a cross-study comparison.",
      "attrs": {},
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "16e4a039-a3fc-41b2-81af-80e32e57b122",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.011,
        "w": 0.66,
        "x": 0.127,
        "y": 0.971
      },
      "kind": "source-note",
      "text": "**Li 2014; *** Pasha 2018; ****Jiang 2011 (Vldlr: Very Low-Density Lipoprotein receptor knock-out mice)",
      "attrs": {},
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "898e4b88-0a6c-4504-b831-1848a23cf993",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.011,
        "w": 0.249,
        "x": 0.127,
        "y": 0.948
      },
      "kind": "source-note",
      "text": "Silva et al. ARVO 2021 Annual Meeting",
      "attrs": {},
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "fb9390ab-831a-4e4e-bf6d-53d27cff160e",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.022,
        "w": 0.86,
        "x": 0.048,
        "y": 0.102
      },
      "kind": "title",
      "text": "Lesion Volume Decrease with Oral APX3330 in Murine Laser CNV Model Similar to EYLEA® Data",
      "attrs": {},
      "subkind": "action-title",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "e5759a20-aa7d-4979-b38a-6b398b789517",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.86,
        "x": 0.048,
        "y": 0.065
      },
      "kind": "title",
      "text": "Preclinical Data: Oral APX3330 Blocks Neovascularization",
      "attrs": {},
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "a04ff8d2-f612-4b72-87e6-d1279f61d93c",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [],
  "arcBeats": [
    {
      "to": 42,
      "from": 29,
      "beatId": "691510f1-c63c-46db-bda1-6d94434f6f9b",
      "arcName": "The Consultant's Gambit",
      "arcSlug": "consultants-gambit",
      "beatName": "Impact & Next Steps",
      "beatSlug": "consultants-gambit-impact-next-steps",
      "evidence": "Slides 29-42 discuss key takeaways, corporate highlights, and future plans",
      "position": 4,
      "confidence": 0.8,
      "parentBeatName": "Resolution",
      "parentBeatSlug": "resolution"
    }
  ],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}