{
  "docId": "019de517-75a1-7387-968b-d0dc513bf421",
  "docSlug": "e930bfcc8684afb6f5a4dd5442b5166d",
  "documentTitle": "Ocuphire Pharma | Investor Presentation Deck | 42 slides",
  "authorId": "ocuphire-pharma",
  "authorName": "Ocuphire Pharma",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2023-11-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 23,
  "pageCount": 42,
  "prevPage": 22,
  "nextPage": 24,
  "slideType": "other",
  "function": "establish_context",
  "density": "overcrowded",
  "nDataPoints": 10,
  "notes": null,
  "elementsJson": null,
  "metadataConfidence": 0.9,
  "imagePath": null,
  "slideHref": "/slides/019de517-75a1-7387-968b-d0dc513bf421/23",
  "deckHref": "/decks/019de517-75a1-7387-968b-d0dc513bf421",
  "deckJsonHref": "/decks/019de517-75a1-7387-968b-d0dc513bf421.json",
  "deckAnchorHref": "/decks/019de517-75a1-7387-968b-d0dc513bf421#slide-23",
  "components": [
    {
      "bbox": {
        "h": 0.07,
        "w": 0.1,
        "x": 0.7,
        "y": 0.43
      },
      "kind": "image",
      "text": "Pill and human figure",
      "attrs": {},
      "subkind": "illustration",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "3c44356a-349b-48dc-81f1-b29c0c0092f2",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.07,
        "w": 0.1,
        "x": 0.12,
        "y": 0.43
      },
      "kind": "image",
      "text": "Eye with injection",
      "attrs": {},
      "subkind": "illustration",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "3ded7edc-5b18-44fe-9117-4c1df327bd01",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.82,
        "x": 0.09,
        "y": 0.16
      },
      "kind": "image",
      "text": "DRSS scale with eye images",
      "attrs": {},
      "subkind": "illustration",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "68670692-f762-4f4a-b2ac-c2c748986b31",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.19,
        "w": 0.39,
        "x": 0.55,
        "y": 0.54
      },
      "kind": "list",
      "text": "Approvable endpoints for systemic drug in DR include either:\n≥ 3-step DRSS improvement on a binocular scale\n≥ 3-step DRSS worsening on a binocular scale",
      "attrs": {},
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "26a99d9b-5cf6-46c3-b911-95e6faf62d92",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.23,
        "w": 0.4,
        "x": 0.08,
        "y": 0.54
      },
      "kind": "list",
      "text": "Precedent approvable endpoint for locally-delivered drugs (non-systemic) in DR:\n≥ 2-step DRSS improvement in study eye\nAflibercept (PANORAMA trial)\nRanibizumab (RISE/RIDE trials)",
      "attrs": {},
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "3d662dfe-bb26-46cb-ba8e-bae7a9a60a68",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.9,
        "x": 0.05,
        "y": 0.85
      },
      "kind": "paragraph",
      "text": "For oral administration, the binocular DRSS endpoint is distinct from anti-VEGF IVT precedent due to different delivery",
      "attrs": {},
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "8c8de411-61bd-4c46-8401-d7e0ee3109b6",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.07,
        "w": 0.9,
        "x": 0.05,
        "y": 0.33
      },
      "kind": "paragraph",
      "text": "FDA accepts improvement OR worsening (slowing or prevention of progression)¹ of the disease AND DRSS is an established surrogate endpoint for DR",
      "attrs": {},
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "f318e50d-22e9-4254-9f73-e6b7f3ce2709",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.06,
        "w": 0.89,
        "x": 0.05,
        "y": 0.92
      },
      "kind": "source-note",
      "text": "Source: ZETA-1 Clinical trial\n1. Nair P, Aiello LP, Gardner TW, Jampol LM, Ferris FL III. Report From the NEI/FDA Diabetic Retinopathy Clinical Trial Design and Endpoints Workshop. Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5127-5142. doi: 10.1167/iovs.16-20356. PMID: 27699406; PMCID: PMC6016432.",
      "attrs": {},
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "4e1776b2-3044-4497-80e8-e101b98c4142",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.9,
        "x": 0.05,
        "y": 0.09
      },
      "kind": "title",
      "text": "Systemic Drugs Should Evaluate DRSS Change in Both Eyes; Formally Confirmed at EOP2 FDA Meeting",
      "attrs": {},
      "subkind": "action-title",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "b7a8fce6-d687-4be5-9807-6a307cd6cb5b",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.04,
        "w": 0.89,
        "x": 0.05,
        "y": 0.05
      },
      "kind": "title",
      "text": "Clinically Meaningful Registration Endpoints in DR",
      "attrs": {},
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "9a01d3bb-eb82-4b6c-a59d-b38fd563a627",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [],
  "arcBeats": [
    {
      "to": 28,
      "from": 17,
      "beatId": "65814d93-901f-41c1-8ee8-b0d5c8ea9369",
      "arcName": "The Consultant's Gambit",
      "arcSlug": "consultants-gambit",
      "beatName": "Evidence & Proof",
      "beatSlug": "consultants-gambit-evidence-proof",
      "evidence": "Slides 17-28 provide clinical trial results and data for APX3330",
      "position": 3,
      "confidence": 0.8,
      "parentBeatName": "Evidence",
      "parentBeatSlug": "evidence"
    }
  ],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}