{ "docId": "019de517-75a1-7387-968b-d0dc513bf421", "docSlug": "e930bfcc8684afb6f5a4dd5442b5166d", "documentTitle": "Ocuphire Pharma | Investor Presentation Deck | 42 slides", "authorId": "ocuphire-pharma", "authorName": "Ocuphire Pharma", "documentKindSlug": "pitchdeck", "documentKindLabel": "Pitch deck", "sourceTypeSlug": "investor_relations", "sourceTypeLabel": "Investor relations", "presentationDate": "2023-11-01 00:00:00", "orientation": "landscape", "aspectRatio": 1.7777778, "pageNumber": 22, "pageCount": 42, "prevPage": 21, "nextPage": 23, "slideType": "other", "function": "establish_context", "density": "overcrowded", "nDataPoints": 100, "notes": null, "elementsJson": null, "metadataConfidence": 1, "imagePath": null, "slideHref": "/slides/019de517-75a1-7387-968b-d0dc513bf421/22", "deckHref": "/decks/019de517-75a1-7387-968b-d0dc513bf421", "deckJsonHref": "/decks/019de517-75a1-7387-968b-d0dc513bf421.json", "deckAnchorHref": "/decks/019de517-75a1-7387-968b-d0dc513bf421#slide-22", "components": [ { "bbox": { "h": 0.03, "w": 0.07, "x": 0.04, "y": 0.94 }, "kind": "image", "text": "Ocuphire", "attrs": {}, "subkind": "logo", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "8e877c96-76da-4f3c-99fa-c07e51b16d86", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.01, "w": 0.02, "x": 0.95, "y": 0.95 }, "kind": "source-note", "text": "22", "attrs": { "numbered": true }, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "a749ae2d-6e53-45f6-b0c2-f252622dfad4", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.04, "w": 0.28, "x": 0.37, "y": 0.79 }, "kind": "source-note", "text": "Note: 15 fellow eyes were CST>320 microns\n(center-involved DME eyes)", "attrs": {}, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "b3ecbf76-9bb9-46f5-ba6b-a89ef7ac5a00", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.01, "w": 0.12, "x": 0.12, "y": 0.95 }, "kind": "source-note", "text": "ZETA-1 Clinical Trial", "attrs": { "numbered": true }, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "fd3252c6-014f-4d4d-887f-1a433daa8e16", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.74, "w": 0.27, "x": 0.05, "y": 0.17 }, "kind": "table", "text": "Demographics\nAPX3330 n=51\nPlacebo n=52\nAge (years) mean (range) 54.3 (26-81) 58.3 (24-78)\nSex: Male n (%) 24 (47%) 26 (50%)\nRace: White n (%) 40 (78%) 41 (79%)\nEthnicity: Hispanic or Latino n (%) 28 (55%) 23 (44%)\nDiabetes Status (years) mean (range) 15 (0-36) 16 (0-58)\nSystolic Blood Pressure (mmHg) mean 136 139\nDiastolic Blood Pressure (mmHg) mean 82 80\nHeart Rate (beats/min) mean 77 76\nHemoglobin A1C (%) mean 8.4 8.3\nBody Mass Index (kg/m^2) mean 31 31", "attrs": {}, "subkind": "data", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "b16bee95-2c6c-4769-b9b6-ca370d276337", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.66, "w": 0.27, "x": 0.69, "y": 0.17 }, "kind": "table", "text": "Key Visual Metrics\nAPX3330 n=51\nPlacebo n=52\nTotal n=103\nBCVA Study Eye Letters (mean) 81 78 80 (20/25 Snellen)\nBCVA Fellow Eye Letters (mean) 76 77 77 (20/32 Snellen)\nOCT CST Study Eye (μm) 270 271 271\nOCT CST Fellow Eye (μm) 292 286 289\nIntraretinal Fluid in the Center of SE Y-21 N-26 Y-12 N-31 Y-33 N-57\nIntraretinal Fluid at the Foveal Center of SE Y-1 N-20 Y-1 N-11 Y-2 N-31\nIntraocular Pressure in Study Eye (mmHg) 15 16 15", "attrs": {}, "subkind": "data", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "c79e251b-2fa8-4921-b61c-8106d79e0485", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.7, "w": 0.32, "x": 0.34, "y": 0.17 }, "kind": "table", "text": "DRSS Scores\nAPX3330 n=49\nPlacebo n=52\nDRSS Score - Study Eye\n47 (Moderately severe to severe NPDR) 22 (43%) 18 (35%)\n53 (Moderately severe to severe NPDR) 25 (49%) 28 (54%)\n61 (Mild proliferative diabetic retinopathy) 4 (8%) 6 (12%)\nDRSS Score - Fellow Eye\n43 or Lower (Mild to moderate NDPR or better) 15 (31%) 13 (25%)\n47 (Moderately severe to severe NPDR) 15 (31%) 20 (38%)\n53 (Moderately severe to severe NPDR) 12 (25%) 10 (19%)\n61 (Mild proliferative diabetic retinopathy) 1 (2%) 4 (8%)\n65 or Higher (Moderate to severe prolif. DR) 6 (12%) 5 (10%)", "attrs": {}, "subkind": "data", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "e7cc351a-d41e-465e-9462-89cb49f7f3bc", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.02, "w": 0.27, "x": 0.06, "y": 0.09 }, "kind": "title", "text": "Well-Balanced Across Arms", "attrs": {}, "subkind": "action-title", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "cfee0349-2566-42c6-9c75-fe5402ddc5ab", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.03, "w": 0.73, "x": 0.06, "y": 0.06 }, "kind": "title", "text": "ZETA-1: Baseline Demographics and Systemic Characteristics", "attrs": {}, "subkind": "headline", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "46d92347-eb56-4093-9830-0046b8f8ec31", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [ { "name": "Table data", "slug": "table-data", "agent": null, "layer": "slide", "matchId": "50640479-b9f9-4aba-bdcd-47e75ff123b5", "evidence": "table/data: DRSS Scores APX3330 n=49 Placebo n=52", "confidence": 0.9 } ], "frameworks": [], "arcBeats": [ { "to": 28, "from": 17, "beatId": "65814d93-901f-41c1-8ee8-b0d5c8ea9369", "arcName": "The Consultant's Gambit", "arcSlug": "consultants-gambit", "beatName": "Evidence & Proof", "beatSlug": "consultants-gambit-evidence-proof", "evidence": "Slides 17-28 provide clinical trial results and data for APX3330", "position": 3, "confidence": 0.8, "parentBeatName": "Evidence", "parentBeatSlug": "evidence" } ], "loops": [], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }