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  "documentTitle": "GH Research | Investor Presentation Deck | 30 slides",
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  "authorName": "GH Research",
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      "kind": "diagram",
      "text": "GH001 Administration\nDay 1\nKey Assessments\nMADRS H2\nPE Scale\nSafety\nMADRS D1\nCognitive function\nSafety\nDay 7\nMADRS D7\nCognitive function\nSafety",
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      "text": "Phase 2 (IDR)\nTRD¹ (n=8)\nGH001 IDR 6, 12, 18 mg to achieve PE (up to 3 doses, 3h interval)\nPrimary Endpoint:\nMADRS remission day 7 (MADRS≤10)",
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      "kind": "list",
      "text": "Phase 1 (Single Dose)\nTRD¹ (n=8)\nGH001 12 mg (n=4)\nGH001 18 mg (n=4)\nPrimary Endpoint:\nSafety until day 7",
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      "kind": "source-note",
      "text": "2023© GH Research PLC",
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      "text": "15",
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      "kind": "source-note",
      "text": "¹Defined as inadequate response to at least two adequate courses of pharmacological therapy or one adequate course of pharmacological therapy and at least one adequate course of evidence-based psychotherapy",
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      "kind": "source-note",
      "text": "TRD, Treatment-Resistant Depression; PE, Peak Experience; MADRS, Montgomery-Åsberg Depression Rating Scale; IDR, Individualized Dosing Regimen; H, Hour; D, Day",
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      "text": "Design of Phase 1/2 Trial in TRD (GH001-TRD-102)",
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      "evidence": "The document presents a clear 'why' for GH001, highlighting its potential to provide ultra-rapid, durable remissions",
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