{ "docId": "019de516-01ce-701d-bd9b-acac15fa9fab", "docSlug": "a13be9775a99db49a0c5c2ac3ee2ea88", "documentTitle": "Oculis | Investor Conference Presentation Deck | 39 slides", "authorId": "oculis", "authorName": "Oculis", "documentKindSlug": "conference-presentation", "documentKindLabel": "Conference presentation", "sourceTypeSlug": "investor_relations", "sourceTypeLabel": "Investor relations", "presentationDate": "2023-06-01 00:00:00", "orientation": "landscape", "aspectRatio": 1.7777778, "pageNumber": 9, "pageCount": 39, "prevPage": 8, "nextPage": 10, "slideType": "problem_statement", "function": "diagnose_problem", "density": "overcrowded", "nDataPoints": 6, "notes": null, "elementsJson": null, "metadataConfidence": 1, "imagePath": null, "slideHref": "/slides/019de516-01ce-701d-bd9b-acac15fa9fab/9", "deckHref": "/decks/019de516-01ce-701d-bd9b-acac15fa9fab", "deckJsonHref": "/decks/019de516-01ce-701d-bd9b-acac15fa9fab.json", "deckAnchorHref": "/decks/019de516-01ce-701d-bd9b-acac15fa9fab#slide-9", "components": [ { "bbox": { "h": 0.12, "w": 0.106, "x": 0.208, "y": 0.189 }, "kind": "image", "text": null, "attrs": null, "subkind": "illustration", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "a2b31770-5146-4f51-8128-6c6bd283e40e", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.05, "w": 0.11, "x": 0.85, "y": 0.04 }, "kind": "image", "text": "Oculis", "attrs": null, "subkind": "logo", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "258079b0-4933-4e0b-95da-04dffec11ec4", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.09, "w": 0.26, "x": 0.66, "y": 0.21 }, "kind": "list", "text": "33% DME with moderate to severe visual impairment (2)", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "03bf9afb-2ca7-443b-9c6c-c8b07c446352", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.02, "w": 0.22, "x": 0.34, "y": 0.56 }, "kind": "list", "text": "1 X Lack of pre-invasive treatment", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "07a821f7-d974-4d8f-9519-9a789b174fe7", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.06, "w": 0.26, "x": 0.33, "y": 0.64 }, "kind": "list", "text": "~ 19% of patients with good vision experience deterioration by ≥ 5 letters over 2 years(3)", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "126a2ed2-ad44-4652-8af3-e8b5a47457b0", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.05, "w": 0.15, "x": 0.77, "y": 0.56 }, "kind": "list", "text": "3 X 40% Inadequate response", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "2c890f60-df56-4d17-9c29-b761f7faa97b", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.02, "w": 0.15, "x": 0.77, "y": 0.64 }, "kind": "list", "text": "Low anti-VEGF response rate(5)", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "3d88747e-b4eb-4843-9e3c-44c8e0e10e90", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.05, "w": 0.11, "x": 0.62, "y": 0.56 }, "kind": "list", "text": "2 60% Adequate response", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "5b9b3c08-5697-4632-ad20-38a58837ec0a", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.09, "w": 0.19, "x": 0.47, "y": 0.21 }, "kind": "list", "text": "43% DME with mild visual impairment (2)", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "9c9f09a1-e91e-4083-9e97-8343e21f482f", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.04, "w": 0.21, "x": 0.34, "y": 0.43 }, "kind": "list", "text": "1st line Observation Laser", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "baf51fcd-15cc-4231-88d5-12a7466bcf0e", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.04, "w": 0.15, "x": 0.77, "y": 0.68 }, "kind": "list", "text": "Combination to drive efficacy and / or durability", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "cb89f59f-6a99-4a7f-a732-87d750c9459b", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.09, "w": 0.15, "x": 0.32, "y": 0.21 }, "kind": "list", "text": "24% DME recent onset (2)", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "d961da91-f506-4b28-83ff-18caced19bac", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.07, "w": 0.21, "x": 0.65, "y": 0.43 }, "kind": "list", "text": "1st line Anti-VEGF Laser Steroid implant", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "f05f53c0-dd11-4ae1-a5d1-82a5a9225c16", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.03, "w": 0.54, "x": 0.23, "y": 0.85 }, "kind": "paragraph", "text": "Addressable US patient population: 1.2 million(4)(6)", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "44b2773f-351b-4d26-ad61-7fc6e45ff31b", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.07, "w": 0.17, "x": 0.03, "y": 0.19 }, "kind": "paragraph", "text": "Patient presents with DME symptoms Diagnosed by OCT (1)", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "727c577d-05f7-4e24-96ce-c643a725b126", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.04, "w": 0.09, "x": 0.11, "y": 0.43 }, "kind": "paragraph", "text": "Current Treatment", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "bbb90e0d-30c4-4de4-9290-f9736fcfedff", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.02, "w": 0.5, "x": 0.34, "y": 0.34 }, "kind": "paragraph", "text": "DME Disease Progression and Treatment Landscape", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "c441a836-d2dd-44da-9818-4470c003c824", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.02, "w": 0.09, "x": 0.11, "y": 0.66 }, "kind": "paragraph", "text": "Unmet Needs", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "e3859db8-fb4f-4910-bc3b-f758b65b2ef6", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.07, "w": 0.84, "x": 0.029, "y": 0.906 }, "kind": "source-note", "text": "(1) Optical coherence tomography (OCT) imaging.\n(2) Baseline Demographics and Clinical Characteristics of Treatment-Naïve Patients with Diabetic Macular Edema Listed in the IRIS Registry\n(Table S1) www.aao.org\n(3) Baker, Carl W., et al. \"Effect of initial management with aflibercept vs laser photocoagulation vs observation on vision loss among patients with\ndiabetic macular edema involving the center of the macula and good visual acuity: a randomized clinical trial.\" Jama 321.19 (2019): 1880-1894.\n(4) Gonzalez 2016 Early and Long-term Responses to VEGF Therapy in DME: Analysis of protocol I data\n(5) Kiss 2014; Berenger and Kiss, Feb. 2016, Real-world Utilization of VEGF agents (DME section), Review of Ophthalmology\nhttps://www.reviewofophthalmology.com/article/realworld-utilization-of-antivegf-agents\n(6) Decision Resources Group: DME - DR Landscape Forecast - Disease Landscape Forecast 2020", "attrs": null, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "835e997c-5fde-4ad7-acc7-756a5a016d31", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.08, "w": 0.82, "x": 0.026, "y": 0.04 }, "kind": "title", "text": "OCS-01 | Current DME Treatment Paradigm Leaves Two Patient Segments Undertreated and Losing Vision", "attrs": null, "subkind": "headline", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "52c70360-3886-415a-a8b7-3fea065f0a68", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [], "frameworks": [], "arcBeats": [ { "to": 9, "from": 7, "beatId": "00f03370-ab36-4c23-9d3e-2630b9379725", "arcName": "The Consultant's Gambit", "arcSlug": "consultants-gambit", "beatName": "Problem & Complication", "beatSlug": "consultants-gambit-problem-complication", "evidence": "Slides 7-9 highlight the limitations of current treatments for DME and DED.", "position": 1, "confidence": 0.8, "parentBeatName": "Complication", "parentBeatSlug": "complication" } ], "loops": [ { "to": 9, "from": 7, "name": "Cost Of Inaction", "slug": "27-cost-of-inaction", "bestFor": "Urgent budget requests, compliance, risk mitigation", "matchId": "69d88c96-6601-41ed-82a1-c55c6033ca19", "evidence": "Slides 7-9 emphasize the limitations and consequences of current treatments.", "position": 0, "objective": "Highlight the cost of inaction for current DME and DED treatments", "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point", "confidence": 0.7, "description": "Quantify what happens if the audience does nothing" } ], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }