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  "documentTitle": "Legend Biotech | Investor Presentation Deck | 26 slides",
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  "authorName": "Legend Biotech",
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  "presentationDate": "2025-04-01 00:00:00",
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  "notes": "The slide uses a schematic diagram to illustrate the 'Armored' CAR-T mechanism.",
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      "text": "Schematic of CAR and Armor mechanism",
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      "text": "PRECLINICAL & Clinical Development strategy: Well-tolerated in vivo; US IND cleared Nov 2022; Orphan Drug Designation June 2023; Actively recruiting at four sites",
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      "text": "TARGET: DLL-3, a promising target with prevalent & homogeneous expression in SCLC (~80% positive) and other neuroendocrine tumors; Minimal to no expression in normal tissues",
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      "text": "MoA/Scientific Rationale: Tandem humanized binders with high affinity and specificity; An armor overcoming suppressive TME to promote CAR-T cell expansion, persistence and infiltration",
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      "text": "For Small Cell Lung Cancer",
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      "kind": "title",
      "text": "LB2102: Legend Armored CAR-T Targeting DLL-3",
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