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  "notes": "The chart demonstrates superior efficacy of the lead compound over existing treatments (Benznidazole and E1224) in a model that mirrors human clinical outcomes.",
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      "text": "For benznidazole, E1224, and posaconazole, mouse models did not predict the clinical trial failure, hence the importance of this NHP model to de-risk nonclinical efficacy",
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      "text": "AN2-502998: only compound to date to cure non-human primates (NHPs) with long-term, naturally acquired infection of diverse T. cruzi genetic types",
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