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      "text": "Study investigated the antitumor responses to NPRL2 gene therapy on anti-PD1 resistant KRAS/STK11 mutant NSCLC in a humanized mouse model. Humanized mice were treated with NPRL2 gene therapy, Keytruda®, or the combination. A dramatic antitumor effect was observed by NPRL2 treatment, whereas Keytruda was largely ineffective. NPRL2 gene therapy induces antitumor activity on KRAS/STK11 mutant anti-PD1 resistant NSCLC through DC mediated antigen presentation and cytotoxic immune cell activation.",
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