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  "documentTitle": "BenevolentAI | Investor Presentation Deck | 31 slides",
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  "notes": "The slide outlines a standard clinical trial structure (SAD, Food Effect, MAD) and highlights the competitive advantage of a clean safety profile compared to historical PDE10 inhibitors.",
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      "text": "Study objectives: assess the safety and tolerability of single and multiple oral doses, and the effect of food on pharmacokinetic profile of BEN-8744 in healthy volunteer subjects (18-65 yrs)",
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      "text": "Part A: Single Ascending Dose (SAD); Part B: Food Effect; Part C: Multiple Ascending dose (MAD)",
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      "text": "MAD study, subjects were dosed twice daily for 14 consecutive days. BEN-8744 or placebo was administered to 8 healthy subjects (BEN-8744 n=6; placebo n=2) in both the single and multiple dose cohorts. In total 6 SAD and 2 MAD cohorts were completed.",
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      "text": "Importance of Phase Ia results: PDE10s previously studied for CNS indications - failed to progress due to dose limiting CNS mediated side effects. A clean safety profile through SAD and MAD doses is a big step forward.",
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      "text": "BEN-8744 Phase Ia",
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