{
  "docId": "019de077-2202-715b-adea-57c1f9ae9ce5",
  "docSlug": "719db50244a96da2bbf79cc8f7d91684",
  "documentTitle": "Arbutus Biopharma | Investor Presentation Deck | 26 slides",
  "authorId": "arbutus-biopharma",
  "authorName": "Arbutus Biopharma",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2024-06-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 13,
  "pageCount": 26,
  "prevPage": 12,
  "nextPage": 14,
  "slideType": "traction",
  "function": "show_traction",
  "density": "dense",
  "nDataPoints": 18,
  "notes": "Data presented at EASL 2024. Includes specific patient counts and percentages for Cohorts A1 and A2.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de077-2202-715b-adea-57c1f9ae9ce5/13",
  "deckHref": "/decks/019de077-2202-715b-adea-57c1f9ae9ce5",
  "deckJsonHref": "/decks/019de077-2202-715b-adea-57c1f9ae9ce5.json",
  "deckAnchorHref": "/decks/019de077-2202-715b-adea-57c1f9ae9ce5#slide-13",
  "components": [
    {
      "bbox": {
        "h": 0.6,
        "w": 0.45,
        "x": 0.52,
        "y": 0.23
      },
      "kind": "list",
      "text": "Key Findings: More patients from the 24-week IFN Cohorts reached and maintained undetectable HBsAg; Patients with sustained HBsAg loss had high anti-HBs levels; Imdusiran and 24 weeks of IFN was safe; All 6 undetectable patients discontinued NA therapy.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "4111b380-4909-4618-8ddd-466cea0b30c4",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.4,
        "x": 0.05,
        "y": 0.87
      },
      "kind": "paragraph",
      "text": "W: week; EOT: end-of-treatment; Next Assay LLOD=0.005 IU/mL",
      "attrs": null,
      "subkind": "footnote",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "3179860f-0070-4393-955a-2dc8af33a56d",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.4,
        "x": 0.34,
        "y": 0.93
      },
      "kind": "subtitle",
      "text": "Functional Cure: undetectable HBV DNA and HBsAg with or without anti-HBs that is maintained for six months after discontinuing all therapy.",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "517af4c2-111c-44e1-9c0c-522364864e38",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.6,
        "w": 0.45,
        "x": 0.05,
        "y": 0.23
      },
      "kind": "table",
      "text": "Number of Patients with Undetectable HBsAg at Key Timepoints",
      "attrs": null,
      "subkind": "data",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "40f41b30-6335-4230-81d9-4954d00650c9",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.9,
        "x": 0.05,
        "y": 0.05
      },
      "kind": "title",
      "text": "IM-PROVE I: Imdusiran with Short Courses of IFN Leads to Undetectable HBsAg and Sustained HBsAg Loss",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "757cf38b-5afa-4403-a5a8-ad3b3f3322bb",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "Table data",
      "slug": "table-data",
      "agent": null,
      "layer": "slide",
      "matchId": "2ef5d537-a141-46d4-9fd1-c3c90e465946",
      "evidence": "The slide includes a table/data, which is used to present specific information.",
      "confidence": 0.7
    }
  ],
  "frameworks": [],
  "arcBeats": [
    {
      "to": 17,
      "from": 13,
      "beatId": "a03442fb-e554-4013-a27a-a70f868887ac",
      "arcName": "Problem-Agitate-Solution",
      "arcSlug": "problem-agitate-solution",
      "beatName": "Traction",
      "beatSlug": null,
      "evidence": "The document showcases positive clinical trial results for Imdusiran and AB-101.",
      "position": 2,
      "confidence": 0.8,
      "parentBeatName": null,
      "parentBeatSlug": null
    }
  ],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}