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  "documentTitle": "CARGO Therapeutics | IPO Presentation Deck | 29 slides",
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  "authorName": "CARGO Therapeutics",
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  "presentationDate": "2024-03-01 00:00:00",
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  "notes": "The slide uses a funnel diagram to represent the screening process and bar charts to demonstrate specificity across CD19, CD20, and CD22 targets.",
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      "kind": "diagram",
      "text": "Screening funnel: Molecular design & cloning; CAR expression / antigen binding; Memory & activation phenotype; Cytokines & cell killing; Serial killing; In vivo activity",
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      "text": "Obtain novel, human binders from antibody discovery campaigns for both CD19 and CD20; Screen top 30 CD19 and CD20 binders as mono-specific CARs; Screen permutations of top 5 CD19 and CD20 binders as bi- and tri-specific CARs to determine compatibility; Screen top CD19 and CD20 binders for off-target binding; Optimize plasmid of CRG-023 for titer, expression and activity",
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      "kind": "title",
      "text": "CRG-023 is a CD19, CD20, CD22 CAR T-cell product candidate that incorporates CD2 co-stimulation",
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      "from": 4,
      "name": "Golden Circle",
      "slug": "11-golden-circle",
      "bestFor": "Visionary leadership, brand positioning, mission statements",
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      "evidence": "The loop is opened on slide 4 and closed on slide 28",
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      "objective": "Why does CARGO Therapeutics exist? What is the company's vision?",
      "structure": "The Why (Belief) -> The How (Process) -> The What (Result)",
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