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  "documentTitle": "Boundless Bio | IPO Presentation Deck | 51 slides",
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      "text": "ecDNA+ tumors show enhanced sensitivity to CHK1 (CHEK1) genetic knockout",
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      "text": "Role of CHK1 in RS: Halt origin firing, Stabilize stalled forks, Pause cell cycle, Orchestrate DNA repair, Maintain cell viability",
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      "text": "High copy number amplification on ecDNA results in RS. Consequently, ecDNA amplified cells have significantly elevated reliance on CHK1 for survival. Therapeutic inhibition of CHK1 further exacerbates RS, resulting in synthetic lethality in ecDNA+ cancer cells.",
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      "text": "Inhibition of Checkpoint Kinase 1 (CHK1) is synthetic lethal in ecDNA+ cancer cells",
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