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  "notes": "Includes specific patient subgroup metrics (ORR, tumor shrinkage) and longitudinal imaging.",
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      "text": "Reduction in ROS1 G2032R Allele",
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      "text": "Data as of 13 Sep 2022, for patients treated by 01 Sep 2022. CNS, central nervous system; ctDNA, circulating tumor deoxyribonucleic acid; NSCLC, non-small cell lung cancer; ORR, objective response rate; PD, progressive disease; PR, partial response; QD, once daily; SD, stable disease; TKI, tyrosine kinase inhibitor.",
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      "text": "Intracranial Lesions Baseline, 4 weeks, 8 weeks",
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      "text": "KEY: Each unique color indicates data from the same patient across both figures; PD (due to new lesions and/or progression of nontarget lesions); Prior treatments include repotrectinib.",
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      "text": "ROS1 Resistance Mutations: Subgroup with known ROS1 G2032R resistance mutation: ORR: 78% (7/9); 100% (9/9) with tumor shrinkage. One patient with ROS1 D2033N with ongoing PR (-40%) pending confirmation.",
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      "text": "CNS Activity: Intracranial PR in 3/3 patients with measurable (>10 mm) CNS metastases; ORR of 73% (8/11) in response-evaluable patients with history of CNS metastases; No CNS progression observed in any of the 35 treated patients.",
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      "text": "NVL-520: ARROS-1 Phase 1 Key Subgroups",
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