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  "notes": "Includes clinical trial data from ARROS-1 Phase 1 study.",
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      "text": "Reduction in ROS1 G2032R Allele",
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      "text": "Data as of 13 Sep 2022, for patients treated by 01 Sep 2022.",
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      "text": "NVL-520 Induced Responses in Intracranial Lesions",
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      "text": "ROS1 Resistance Mutations: Subgroup with known ROS1 G2032R resistance mutation: ORR: 78% (7/9); 100% (9/9) with tumor shrinkage. One patient with ROS1 D2033N with ongoing PR (-40%) pending confirmation.",
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      "text": "CNS Activity: Intracranial PR in 3/3 patients with measurable (>10 mm) CNS metastases. ORR of 73% (8/11) in response-evaluable patients with history of CNS metastases. No CNS progression observed in any of the 35 treated patients.",
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      "text": "Source: Drilon A. et al., EORTC-NCI-AACR 2022.",
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