{
  "docId": "019de076-b731-71da-a78f-007719e300bb",
  "docSlug": "1616e8b22ac58e7f024f1153201d610f",
  "documentTitle": "Nuvalent | Investor Presentation Deck | 42 slides",
  "authorId": "nuvalent",
  "authorName": "Nuvalent",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2024-01-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 37,
  "pageCount": 42,
  "prevPage": 36,
  "nextPage": 38,
  "slideType": "why_now",
  "function": "argue_timing",
  "density": "dense",
  "nDataPoints": 7,
  "notes": "Uses a side-by-side comparison framework to contrast 2L+ (salvage) and 1L (front-line) market opportunities.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de076-b731-71da-a78f-007719e300bb/37",
  "deckHref": "/decks/019de076-b731-71da-a78f-007719e300bb",
  "deckJsonHref": "/decks/019de076-b731-71da-a78f-007719e300bb.json",
  "deckAnchorHref": "/decks/019de076-b731-71da-a78f-007719e300bb#slide-37",
  "components": [
    {
      "bbox": {
        "h": 0.61,
        "w": 0.69,
        "x": 0.155,
        "y": 0.265
      },
      "kind": "framework",
      "text": "Comparison of 2L+ vs 1L treatment landscape",
      "attrs": null,
      "subkind": "instance",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "c70db7f2-b770-4ed0-b182-55c72f8e5e32",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.25,
        "w": 0.31,
        "x": 0.52,
        "y": 0.52
      },
      "kind": "list",
      "text": "Potential to address combined medical needs; Opportunity to drive deep, durable responses; Favorable preliminary safety profile",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "736abd5a-3440-46d3-9943-e0ab679fd5f2",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.35,
        "w": 0.32,
        "x": 0.17,
        "y": 0.44
      },
      "kind": "list",
      "text": "Clinical activity observed in heavily pretreated patients with ROS1+ NSCLC: Who likely exhausted all available therapies (ORR: 50%); With ROS1 resistance mutations (ORR: 78%); With history of CNS metastasis (ORR: 73%)",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "932f13e1-bb9a-4818-99dc-31fe3569bb67",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.82,
        "x": 0.058,
        "y": 0.89
      },
      "kind": "source-note",
      "text": "Sources: Cortellis Sales and Forecasts, accessed November 2023; Lin et al., J Thorac Oncol 2017; Gainor et al, JCO Precision Oncol 2017; Ou and Zhu Lung Cancer 2019; Patil et al, JTO 2018; Drilon A. et al., EORTC-NCI-AACR 2022.",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "342214bd-ca7a-4294-b0a6-228d66df1a80",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.025,
        "w": 0.65,
        "x": 0.058,
        "y": 0.19
      },
      "kind": "title",
      "text": "Opportunity to both move up the treatment paradigm & grow the market with deep, durable responses",
      "attrs": null,
      "subkind": "action-title",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "5db93ca5-346c-496a-82af-6ffe427923f0",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.035,
        "w": 0.42,
        "x": 0.058,
        "y": 0.118
      },
      "kind": "title",
      "text": "Potential Best-in-class Profile for ROS1+ NSCLC",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "e477c409-5807-4181-a6d2-84376de2ad16",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "2x2 matrix",
      "slug": "matrix-2x2",
      "agent": null,
      "layer": "slide",
      "matchId": "6ad1effb-4b95-4b5a-bff9-5113d9ffeed2",
      "evidence": "framework/instance: Comparison of 2L+ vs 1L treatment landscape",
      "confidence": 0.5
    }
  ],
  "frameworks": [
    {
      "name": "comparison-frame",
      "slug": null,
      "matchId": "7b1ff341-a6f4-4870-990c-48277d05203a",
      "evidence": "Side-by-side comparison of 2L+ and 1L clinical profiles",
      "confidence": 0.9
    }
  ],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}