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  "notes": "Includes a formula for Selectivity index and a legend for various compound mutations.",
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      "text": "Unbound brain:plasma ratio for Lorlatinib vs NVL-655",
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      "text": "Head-to-head clinical studies comparing NVL-655 with currently approved or investigational therapies have not been conducted. CNS, central nervous system; IC50, half-maximal inhibitory concentration; PO, orally; pTRKB, BDNF-stimulated TRKB phosphorylation. Source: Lin J.J. et al., AACR-NCI-EORTC 2023. Mizuta, H. et al. WCLC-IASLC 2022; Tangpeerachaikul, A. et al. AACR-NCI-EORTC 2021; Pelish, H. et al. AACR 2021. Data presented here reflect updated values following additional repeat testing.",
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