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  "documentTitle": "Immix Biopharma | Investor Presentation Deck | 64 slides",
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  "notes": "Includes citations from Nature Signal Transduction and Targeted Therapy and Nature Medicine.",
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      "text": "CD3ζ / 4-1BB domain structure diagram",
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      "text": "CARs rely on activation of CAR-T cells through CD3ζ derived immunoreceptor tyrosine-based activation motifs (ITAMs), typically 3 ITAM motifs per CAR. NXC-201 adds a positively charged amino acid (lysine) next to a tyrosine phosphorylation site.",
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      "text": "Impeding phosphorylation of ITAM1 (by affecting protein folding dynamics which block the tyrosine site), thus reducing intracellular reactivity. Adding an additional site for ubiquitination, allowing the CAR to be marked for degradation more rapidly than a traditional CAR.",
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      "text": "We hypothesized that the redundancy of CD28 and CD3ζ signaling in a chimeric antigen receptor (CAR) design incorporating all three CD3ζ immunoreceptor tyrosine-based activation motifs (ITAMs)11,13 may foster counterproductive T cell differentiation and exhaustion. Therefore, we calibrated ITAM activity by mutating tyrosine residues to impede their phosphorylation and downstream signaling",
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      "text": "In activated T cells, the CD3ζ chain gets ubiquitinated by CBLB at its multiple lysine residues and induces degradation of surface TCRs",
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      "text": "Source:: Feucht J, et al. Nat Med. 2019; Shah K, et al. Signal Transduct Target Ther. 2021",
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      "kind": "title",
      "text": "Proprietary Optimized CD3ζ + CD8 Delivers “Digital” Intracellular Signaling, Eliminates Neurotoxicity, Reduces CRS Duration",
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