{
  "docId": "019de076-9434-73df-8e70-401e13bb3d65",
  "docSlug": "692690be0ea25b83b6a4c7490ff14999",
  "documentTitle": "BioAtla | Investor Presentation Deck | 55 slides",
  "authorId": "bioatla",
  "authorName": "BioAtla",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2024-01-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 30,
  "pageCount": 55,
  "prevPage": 29,
  "nextPage": 31,
  "slideType": "problem_statement",
  "function": "frame_problem",
  "density": "dense",
  "nDataPoints": 2,
  "notes": "The slide presents clinical evidence linking AXL expression to poor patient outcomes in two different cohorts.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de076-9434-73df-8e70-401e13bb3d65/30",
  "deckHref": "/decks/019de076-9434-73df-8e70-401e13bb3d65",
  "deckJsonHref": "/decks/019de076-9434-73df-8e70-401e13bb3d65.json",
  "deckAnchorHref": "/decks/019de076-9434-73df-8e70-401e13bb3d65#slide-30",
  "components": [
    {
      "bbox": {
        "h": 0.15,
        "w": 0.44,
        "x": 0.53,
        "y": 0.7
      },
      "kind": "callout",
      "text": "Lower overall survival (OS) in patients with early stage, surgically resected lung adenocarcinoma with high levels of tissue AXL",
      "attrs": null,
      "subkind": "primary",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "04b96b91-7b87-4fc0-ac11-53ff95009648",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.44,
        "x": 0.03,
        "y": 0.7
      },
      "kind": "callout",
      "text": "In a cohort of 98 patients with metastatic NSCLC, OS was significantly worse for those patients with high AXL expression by IHC",
      "attrs": null,
      "subkind": "primary",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "d18bbe58-d5cc-4fbb-9062-e550921b7383",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.45,
        "w": 0.35,
        "x": 0.55,
        "y": 0.22
      },
      "kind": "chart",
      "text": "Kaplan-Meier survival curve for early stage lung adenocarcinoma",
      "attrs": null,
      "subkind": "line",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "6473f78a-f7f4-48ed-ba5a-06ab897bf0de",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.45,
        "w": 0.35,
        "x": 0.05,
        "y": 0.22
      },
      "kind": "chart",
      "text": "Kaplan-Meier survival curve for metastatic NSCLC cohort",
      "attrs": null,
      "subkind": "line",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "967eb3d4-0cd9-4862-845f-5fe92707a29b",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.3,
        "x": 0.53,
        "y": 0.84
      },
      "kind": "source-note",
      "text": "Reproduced from de Miguel-Pérez D, et al. 2019",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "5f4cf506-3523-40f8-8d24-78d6d8ee10e1",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.3,
        "x": 0.05,
        "y": 0.84
      },
      "kind": "source-note",
      "text": "Wu et al., J Cancer Res and Clin Oncol, 2017",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "dcfb9a77-81ed-4194-9d67-623bea065ba8",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.75,
        "x": 0.03,
        "y": 0.08
      },
      "kind": "title",
      "text": "AXL expression is associated poor prognosis in metastatic NSCLC",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "7798f733-633c-4a88-ab50-a03269beef7a",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "Evidence Matrix",
      "slug": "evidence-matrix",
      "agent": "Designer",
      "layer": "slide",
      "matchId": "ec64ed66-28a6-46f5-930c-527fad13e782",
      "evidence": "chart/line: Kaplan-Meier survival curve for early stage lung adenocarcinoma",
      "confidence": 0.7
    }
  ],
  "frameworks": [
    {
      "name": "evidence-matrix",
      "slug": null,
      "matchId": "6bac0824-0f41-4590-b619-4bcd194c24a2",
      "evidence": "Presents two distinct clinical studies to support the thesis of AXL as a poor prognostic marker.",
      "confidence": 0.8
    }
  ],
  "arcBeats": [
    {
      "to": 30,
      "from": 30,
      "beatId": "c41c7a02-9893-4d75-b19b-128a0ec29ee5",
      "arcName": "The Sequoia Pitch",
      "arcSlug": "sequoia-pitch",
      "beatName": "Problem",
      "beatSlug": "sequoia-pitch-problem",
      "evidence": "The problem is clearly stated on page 30, highlighting the limitations of current cancer therapies.",
      "position": 0,
      "confidence": 0.8,
      "parentBeatName": "Complication",
      "parentBeatSlug": "complication"
    }
  ],
  "loops": [
    {
      "to": 30,
      "from": 30,
      "name": "Cost Of Inaction",
      "slug": "27-cost-of-inaction",
      "bestFor": "Urgent budget requests, compliance, risk mitigation",
      "matchId": "fa596b49-ad10-48ec-b55e-be7efa8d3736",
      "evidence": "The problem statement on page 30 implies the cost of inaction.",
      "position": 0,
      "objective": "Highlight the cost of inaction in cancer therapy",
      "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
      "confidence": 0.7,
      "description": "Quantify what happens if the audience does nothing"
    }
  ],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}