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      "text": "Clinical Activity Based on Preclinical Data: Strong antitumor activity in a wide variety of heme and solid tumors with an emerging signature (undisclosed)",
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      "text": "KT-253 is a novel, highly potent and selective heterobifunctional MDM2 degrader; MDM2 is the E3 ligase that modulates p53; p53 is NOT mutated in 50% of tumors; MDM2 overexpression inactivates p53; Large opportunity in wide variety of cancers.",
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