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  "documentTitle": "Nuvalent | Investor Presentation Deck | 52 slides",
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  "presentationDate": "2023-11-01 00:00:00",
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  "notes": "The chart displays patient-level data categorized by dose and mutation type, highlighting the efficacy of NVL-655 in clearing specific ALK resistance mutations.",
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      "text": "Clearance of ALK Mutations Detected in Plasma",
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      "kind": "disclaimer",
      "text": "Pt, Patient. Data are shown for all treated patients with ALK mutations detected on Cycle 1 Day 1 and with at least one follow-up assessment. a Refers to single or compound mutations. b ALK mutant variant of unknown significance.",
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      "text": "G1202R Mutation, I1171X (X = N or T) Mutation, Other Mutation, Received prior lorlatinib",
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      "text": "100% clearance observed in 14/16 patients with centrally confirmed ALK G1202R or I1171X mutations, of whom 13 had received prior lorlatinib",
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      "text": "Pharmacodynamics | NVL-655 Induced Clearance of Diverse ALK Resistance Mutation Alleles",
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      "evidence": "Slides 29-40 present preclinical and clinical trial results for NVL-655.",
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