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  "notes": "The chart displays dose-dependent exposure levels exceeding multiple efficacy thresholds for ROS1 variants in CNS and peripheral tissues.",
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      "text": "Data as of 13 Sep 22, for patients treated by 01 Sep 2022. CNS, central nervous system; h, hours; PK, pharmacokinetics; QD, once daily; SD, standard deviation. Source: Drilon A. et al., EORTC-NCI-AACR 2022.",
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      "text": "NVL-520 exposure exceeded target levels that provide regression in preclinical models. Favorable pharmacokinetics: Low intra-cohort patient PK variability, Exposure increasing with increasing dose level, Half-life of approximately 20h supports QD dosing",
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