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  "documentTitle": "Nuvalent | Investor Presentation Deck | 52 slides",
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  "notes": "The slide uses a bar chart to show brain penetrance and a grouped bar chart to show selectivity index, highlighting the drug's potential to avoid off-target CNS effects.",
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      "kind": "chart",
      "text": "Selectivity Index for NVL-520, Crizotinib, Entrectinib, Repotrectinib",
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      "text": "Unbound brain:plasma ratio for NVL-520 vs Lorlatinib",
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      "text": "IC50, half-maximal inhibitory concentration; PO, orally; pTRK, BDNF-stimulated TRKB phosphorylation. Head-to-head clinical studies comparing NVL-520 with currently approved or investigational therapies have not been conducted. Above data from preclinical studies. Sources: Drilon A. et al., Cancer Discov (2023) 13 (3): 598–615.; Tangpeerachaikul, A. et al., EORTC-NCI-AACR 2021; Data on file.",
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      "text": "Preclinical | NVL-520 is a Brain Penetrant, ROS1-Selective Inhibitor with the Potential to Avoid TRK-Related CNS Adverse Events",
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