{
  "docId": "019de076-4eee-72eb-9f75-bef42550a1c1",
  "docSlug": "3c2d586ebe2940705b3e5004470d76e3",
  "documentTitle": "Kymera | Investor Presentation Deck | 41 slides",
  "authorId": "kymera",
  "authorName": "Kymera",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2023-11-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 18,
  "pageCount": 41,
  "prevPage": 17,
  "nextPage": 19,
  "slideType": "appendix_data",
  "function": "analyze_data",
  "density": "balanced",
  "nDataPoints": 15,
  "notes": "The slide highlights a favorable safety profile with no serious adverse events (SAEs) or drug-related infections.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de076-4eee-72eb-9f75-bef42550a1c1/18",
  "deckHref": "/decks/019de076-4eee-72eb-9f75-bef42550a1c1",
  "deckJsonHref": "/decks/019de076-4eee-72eb-9f75-bef42550a1c1.json",
  "deckAnchorHref": "/decks/019de076-4eee-72eb-9f75-bef42550a1c1#slide-18",
  "components": [
    {
      "bbox": {
        "h": 0.22,
        "w": 0.92,
        "x": 0.04,
        "y": 0.68
      },
      "kind": "paragraph",
      "text": "No SAEs, no drug-related infections, and no AEs observed leading to dose interruption or discontinuation. No QTc-related AEs observed. QTc declines to baseline with continued dosing and sustained plasma exposure through Day 28. Profile is maintained through day 42 upon cessation of dosing after Day 28",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "9df1a4e5-0449-4470-b4f1-2ebac21a50d6",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.38,
        "w": 0.92,
        "x": 0.04,
        "y": 0.16
      },
      "kind": "table",
      "text": "Adverse Event (Preferred Term) | # of Patients | Severity (# of Pts) | Outcome (# of Pts) | Headache | 6 | Mild (5) Severe (1) | Recovered (6) | Fatigue | 4 | Mild (4) | Recovered (4) | Diarrhea | 2 | Mild (2) | Recovered (2)",
      "attrs": null,
      "subkind": "data",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "c190ab9b-a5b0-484f-9670-6dd592076563",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.06,
        "w": 0.82,
        "x": 0.09,
        "y": 0.04
      },
      "kind": "title",
      "text": "Adverse Events Related to KT-474 (Occurring in >1 Patient)",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "a1f3062d-f490-4137-ae5d-c4d284d4630b",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "Table data",
      "slug": "table-data",
      "agent": null,
      "layer": "slide",
      "matchId": "7cca3dd5-927f-407c-b992-9876594d21eb",
      "evidence": "table/data: Adverse Event (Preferred Term) | # of Patients | Severity (# of Pts) | Outcome (# of Pts) | Headache | 6 | Mild (5) Severe (1) | Recovered (6) | Fatigue | 4 | Mild (4) | Recovered (4) | Diarrhea | 2 | Mild (2",
      "confidence": 0.8
    }
  ],
  "frameworks": [],
  "arcBeats": [
    {
      "to": 19,
      "from": 10,
      "beatId": "76c0c72b-c82b-4ac5-891b-8e3593c8cc1e",
      "arcName": "The Sequoia Pitch",
      "arcSlug": "sequoia-pitch",
      "beatName": "Traction",
      "beatSlug": null,
      "evidence": "The deck showcases encouraging clinical data for lead programs.",
      "position": 2,
      "confidence": 0.8,
      "parentBeatName": null,
      "parentBeatSlug": null
    }
  ],
  "loops": [
    {
      "to": 19,
      "from": 10,
      "name": "Quick Win Big Bet",
      "slug": "47-quick-win-big-bet",
      "bestFor": "Transformation planning, 100-day plans, resource allocation",
      "matchId": "481e5a5e-15c9-4f41-910c-aaa935cd7dad",
      "evidence": "The deck showcases encouraging clinical data for lead programs.",
      "position": 1,
      "objective": "What are the potential benefits of Kymera's platform?",
      "structure": "The Full List -> Quick Wins (Low effort, High impact) -> Big Bets (High effort, High impact) -> Sequenced Roadmap",
      "confidence": 0.6,
      "description": "Separate initiatives into immediate wins and longer-term strategic bets"
    }
  ],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}