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  "notes": "Data cut-off Sep 30, 2023. N=21 patients.",
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      "kind": "callout",
      "text": "IMA203 GEN1 monotherapy continues to be well tolerated at total doses between 1-10x10^9 TCR-T cells (RP2D)",
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      "text": "43% (9/21) with Grade 1 CRS\n48% (10/21) with Grade 2 CRS\nNo dose-dependent increase of CRS",
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      "text": "Expected cytopenia (Grade 1-4) associated with lymphodepletion in all patients\nMild-moderate cytokine release syndrome (CRS) in 90% (19/21) of patients\nOne non-serious, mild (Grade 1) ICANS in DL5\nNo dose-limiting toxicity\nNo IMA203-related deaths",
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      "text": "1 Three cutaneous melanoma patients treated with IMA203, and pending post infusion scan included in safety population, but not efficacy population; 2 ICANS: Immune Effector Cell-Associated Neurotoxicity Syndrome; CRS and ICANS graded by CARTOX criteria (Neelapu et al., 2018)",
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