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  "notes": "The slide uses a biological diagram to illustrate the synergy between CD4 and CD8 T cells in inducing tumor cell death.",
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      "text": "IMA203CD8 GEN2 designed to broaden the clinical potential of IMA203 TCR-T monotherapy by adding functional CD4 T cells via co-transduction of CD8αβ alongside PRAME TCR. Activated CD4 T cells aid activity of other immune cells by releasing cytokines and acquire cytotoxic functions. Functional CD4 T cells mediate longer anti-tumor activity than CD8 T cells and potentiate the anti-tumor activity of the cell product in preclinical studies. Data from CD19 CAR-T-treated leukaemia patients suggest a relevant role of engineered CD4 T cells in long-term durability.",
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      "text": "1Internal data not shown here, published in Bajwa et al. 2021 Journal for Immunotherapy of Cancer; 2 Melenhorst et al. 2022 Nature, Bai et al. 2022 Science Advances",
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      "text": "Differentiated Pharmacology Compared to 1st-Generation TCR-only Approaches",
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      "text": "IMA203CD8 GEN2 – IMA203 TCR-T Monotherapy Leveraging CD8 and CD4 cells",
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