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  "notes": "The chart demonstrates dose-proportional exposure and confirms that doses >= 50 mg QD exceed efficacy thresholds for various ALK mutations in the CNS.",
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      "text": "NVL-655 Pharmacokinetics at Steady State (Day 15)",
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      "text": "Favorable pharmacokinetics: Low intra-cohort variability, Dose proportional exposure, Half-life supports QD dosing. Dose levels >= 50 mg QD may provide increased coverage of single and compound mutations in the CNS.",
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      "text": "Available data for patients enrolled as of 08 Aug 23. Pharmacokinetic data for 200 mg QD cohort are not shown due to immaturity. CNS, central nervous system; h, hours; PK, pharmacokinetics; QD, once daily; SD, standard deviation. a Based on >= 100% tumor growth inhibition (best response) in in vivo models bearing HIP1-ALK, Ba/F3 EML4-ALK v1 G1202R, EML4-ALK v3 G1202R/L1196M, and Ba/F3 EML4-ALK v1 I1171N, respectively, divided by predicted human CNS Kp (brain to plasma ratio). Targets for CNS exceed corresponding periphery values. Source: Lin J.J. et al., AACR-NCI-EORTC 2023.",
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      "text": "Pharmacokinetics | NVL-655 Exposure Achieved Predicted Efficacy Thresholds",
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