{
  "docId": "019de076-0698-71a3-a9aa-98e37bdedc21",
  "docSlug": "bc2296074db02088be88a45da2f9e973",
  "documentTitle": "Mainz Biomed NV | Investor Presentation Deck | 27 slides",
  "authorId": "mainz-biomed-nv",
  "authorName": "Mainz Biomed",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2023-10-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 12,
  "pageCount": 27,
  "prevPage": 11,
  "nextPage": 13,
  "slideType": "other",
  "function": "analyze_data",
  "density": "dense",
  "nDataPoints": 4,
  "notes": "AA = Advanced Adenoma; CRC = Colorectal Cancer. Data source cited at bottom.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de076-0698-71a3-a9aa-98e37bdedc21/12",
  "deckHref": "/decks/019de076-0698-71a3-a9aa-98e37bdedc21",
  "deckJsonHref": "/decks/019de076-0698-71a3-a9aa-98e37bdedc21.json",
  "deckAnchorHref": "/decks/019de076-0698-71a3-a9aa-98e37bdedc21#slide-12",
  "components": [
    {
      "bbox": {
        "h": 0.05,
        "w": 0.9,
        "x": 0.05,
        "y": 0.14
      },
      "kind": "callout",
      "text": "Including AAs detection in screening tests significantly reduces both incidence and mortality",
      "attrs": null,
      "subkind": "primary",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "f3b979e7-d601-4da5-8d17-190ab437b0b9",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.2,
        "w": 0.5,
        "x": 0.05,
        "y": 0.37
      },
      "kind": "list",
      "text": "If a screening tests in 45yr olds and above resulted in: 21% sensitivity for AA: Reduction of CRC incidence by 30%; Reduction of CRC mortality by 47%",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "ae5f3f71-7918-409c-87ff-3db5c49a5496",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.2,
        "w": 0.5,
        "x": 0.05,
        "y": 0.61
      },
      "kind": "list",
      "text": "76% sensitivity for AA: Reduction in CRC incidence by 57%; Reduction in CRC mortality by 67%",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "b15162c1-3df9-4cf8-8bd4-4489d22ffa34",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.1,
        "w": 0.8,
        "x": 0.05,
        "y": 0.23
      },
      "kind": "list",
      "text": "Discussion of CMS decision memo on thresholds of 74% sensitivity, 90% specificity for blood-based screening for CRC. No thresholds set for detection of AA.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "e2fd5a58-7db5-4829-9774-9fbd75e3646a",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.9,
        "x": 0.05,
        "y": 0.81
      },
      "kind": "source-note",
      "text": "Ladabaum U, et al. Counting Advanced Precancerous Lesions as True Positives When Determining Colorectal Cancer Screening Test Specificity, JNCI: Journal of the National Cancer Institute, Volume 114, Issue 7, July 2022, Pages 1040-1043",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "a95b83af-5452-4234-afc5-7fda67c00658",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.8,
        "x": 0.05,
        "y": 0.03
      },
      "kind": "title",
      "text": "Impact of AA sensitivity on CRC Mortality and Incidents Rates",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "399722b4-6992-401a-8313-a8473bdcbce1",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "Analytical method",
      "slug": "analytical-method",
      "agent": null,
      "layer": "slide",
      "matchId": "159f0f52-5f5e-47fd-afda-2bb35b726ab7",
      "evidence": "Discussion of CMS decision memo on thresholds of 74% sensitivity, 90% specificity",
      "confidence": 0.6
    }
  ],
  "frameworks": [],
  "arcBeats": [
    {
      "to": 12,
      "from": 12,
      "beatId": "ea795f03-dff0-48bc-8550-7b4358967691",
      "arcName": "Problem-Agitate-Solution",
      "arcSlug": "problem-agitate-solution",
      "beatName": "Agitate (Make it worse)",
      "beatSlug": "problem-agitate-solution-agitate-make-it-worse",
      "evidence": "The document emphasizes the benefits of including AAs detection in screening tests, implying that current tests are insufficient",
      "position": 1,
      "confidence": 0.8,
      "parentBeatName": "Development",
      "parentBeatSlug": "development"
    }
  ],
  "loops": [
    {
      "to": 12,
      "from": 11,
      "name": "Cost Of Inaction",
      "slug": "27-cost-of-inaction",
      "bestFor": "Urgent budget requests, compliance, risk mitigation",
      "matchId": "cc78fa79-d739-47ee-b64c-54afca15e018",
      "evidence": "The document implies that inaction or insufficient action in CRC screening and detection can lead to significant negative consequences",
      "position": 0,
      "objective": "Highlight the cost of inaction in CRC screening and detection",
      "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
      "confidence": 0.6,
      "description": "Quantify what happens if the audience does nothing"
    }
  ],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}