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  "documentTitle": "Arbutus Biopharma | Investor Presentation Deck | 25 slides",
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  "presentationDate": "2023-10-01 00:00:00",
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  "notes": "Clinical trial data showing individual patient responses over time, including two cases of NA retreatment.",
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      "text": "7 of 9 (78%) subjects remain off NA therapy for 44-64 weeks and all completed imdusiran treatment over 1½ years ago; Most subjects have maintained low HBV DNA levels off treatment; HBsAg remains between -0.8 and -1.6 log10 IU/mL below baseline values; NA discontinuation post-imdusiran treatment appears well tolerated with no ALT flares",
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      "text": "* Patient 53 restarted NA therapy at Investigator’s request after the NA d/c FU W20 visit (pink shaded area). ** Patient 58 restarted therapy after the NA d/c FU W36 visit (pink shaded area).",
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      "kind": "title",
      "text": "AB-729-001: Imdusiran Shows Low Levels of HBV Biomarkers Persisting in cHBV Patients While Off-Treatment",
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      "evidence": "Imdusiran RNAi Therapeutic, Robust HBsAg declines, Imdusiran demonstrates robust and sustained HBsAg declines",
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