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  "documentTitle": "Arbutus Biopharma | Investor Presentation Deck | 25 slides",
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  "presentationDate": "2023-10-01 00:00:00",
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  "notes": "Data shows consistent efficacy across different patient subgroups.",
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      "text": "All Cohorts achieved at least a -1.8 log10 decline in mean HBsAg at the end of the treatment period (Week 48). Mean HBsAg levels remained below baseline values at Follow Up Week 48. No significant differences between doses or intervals.",
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      "text": "Data shown as mean (SE) log10 IU/mL; minimum of 5 subjects/timepoint. Last imdusiran (AB-729) dose Cohort E: Week 44, Cohorts F, I, G, K: Week 40, Cohort J: Week 36; HBsAg Assay LLOQ = 0.07 IU/mL; *N=6; #N=5",
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      "text": "Mean (SE) Baseline and Δ log10 HBsAg by Visit table",
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      "kind": "title",
      "text": "AB-729-001: Robust HBsAg Declines Irrespective of Imdusiran Dose, Dosing Schedule, HBeAg or HBV DNA Status",
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      "evidence": "Imdusiran RNAi Therapeutic, Robust HBsAg declines, Imdusiran demonstrates robust and sustained HBsAg declines",
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