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  "authorName": "Mural Oncology",
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  "notes": "The slide uses a diagram to illustrate the activation of immune cells (NKT, NK, CD4, CD8) by IL-12, leading to IFN-gamma production and subsequent downstream effects.",
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      "text": "Diagram showing IL-12 structure and its activation of NKT, NK, CD4, and CD8 cells to produce IFN-gamma, which then influences T-cell function and ECM/angiogenesis.",
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      "text": "Heterodimeric protein consisting of two covalently linked subunits; Individual components, p35 and p40, are inactive. Anti-tumor efficacy observed in preclinical studies; Driven by activation of innate and adaptive immune compartments and production of IFN-y. Clinical evaluation limited by narrow therapeutic window; Severe toxicities associated with systemic exposure to IL-12 leading to a narrow therapeutic index.",
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      "text": "1. Nguyen KG et. al. Cancer Immunotherapy. Front. Immunol. October 15 2020 11:575597; 2. Vecchio MD et. al. Clin Cancer Res August 15 2007 (13) (16) 4677-4685; 3. Strauss J et. al. Clin Cancer Res January 1 2019 (25) (1) 99-109",
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      "text": "IL-12 is Recognized as a Highly-Potent Proinflammatory Cytokine But Clinical Utility Has Been Limited by Severe Toxicities",
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