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      "text": "AI models outperform biological baselines: De novo designed HCDR3s achieve a 4-fold improvement over random OAS baseline; De novo designed HCDR123s achieve an 11-fold improvement over random OAS baseline",
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      "text": "AI designs are specific: Inputting a mis-matched undesired antigen (e.g., Rat HER2, HER3, VEGF) into the model results in significant performance decrease towards desired antigen; Indicates the model's use of antigen information for sequence designs",
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      "text": "HER2 Binding Rate (%) measured via ACE assay; HCDR3; HCDR123; Zero-shot de novo generated; Human HER2; 10.6; 1.8; Rat HER2; 2.8; 0.5; HER3; 2.9; 0.2; VEGF; 2.5; 0.0; Biological baseline; OAS; 2.68; 0.16; OAS-J; 5.25; 0.32; SAbDab; 3.16; 0.06; Random baseline; Permuted sequences; 0.33; N/A",
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