{
  "docId": "019de075-dd1e-7468-9323-d12fde1b7732",
  "docSlug": "a9cc0c508d45d8985f57408ace49b969",
  "documentTitle": "RayzeBio | IPO Presentation Deck | 41 slides",
  "authorId": "rayzebio",
  "authorName": "RayzeBio",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investment_bank",
  "sourceTypeLabel": "Investment bank",
  "presentationDate": "2023-09-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7761332,
  "pageNumber": 9,
  "pageCount": 41,
  "prevPage": 8,
  "nextPage": 10,
  "slideType": "problem_statement",
  "function": "frame_problem",
  "density": "dense",
  "nDataPoints": 6,
  "notes": "The slide uses a comparison framework to justify the use of alpha-emitting isotopes in targeted radiotherapy.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de075-dd1e-7468-9323-d12fde1b7732/9",
  "deckHref": "/decks/019de075-dd1e-7468-9323-d12fde1b7732",
  "deckJsonHref": "/decks/019de075-dd1e-7468-9323-d12fde1b7732.json",
  "deckAnchorHref": "/decks/019de075-dd1e-7468-9323-d12fde1b7732#slide-9",
  "components": [
    {
      "bbox": {
        "h": 0.09,
        "w": 0.94,
        "x": 0.03,
        "y": 0.16
      },
      "kind": "callout",
      "text": "Alpha radiation causes direct, irreparable double-stranded DNA breaks compared with beta radiation, which typically cause single-stranded breaks via indirect DNA damage",
      "attrs": null,
      "subkind": "primary",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "d52ea826-be97-431a-b626-962981d94bbe",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.6,
        "w": 0.45,
        "x": 0.52,
        "y": 0.3
      },
      "kind": "image",
      "text": "Visual representation of alpha vs beta radiation hitting DNA strands",
      "attrs": null,
      "subkind": "infographic",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "d4ce7eb6-cf6d-47cb-91ea-baa6b8945a65",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.3,
        "w": 0.45,
        "x": 0.03,
        "y": 0.28
      },
      "kind": "list",
      "text": "225Actinium (225Ac), 223Radium: 2 protons + 2 neutrons; Up to 400 times more damaging than β isotopes, linear energy transfer (keV/um): ~80-100; Causes double stranded DNA breaks; Tissue range: 20 to 80 um",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "c7b1a67d-0dbd-43c2-bd86-faea6edef93c",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.3,
        "w": 0.45,
        "x": 0.03,
        "y": 0.6
      },
      "kind": "list",
      "text": "177Lutetium (177Lu), 131Iodine: Electron particle; Linear energy transfer (keV/um): ~0.2-0.5; Causes mostly single stranded DNA breaks; Tissue range: 2 to 11.5 mm",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "d5d90fe7-5394-4a71-9ad4-7076c9246303",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.06,
        "w": 0.5,
        "x": 0.03,
        "y": 0.04
      },
      "kind": "title",
      "text": "Alpha (α) and Beta (β) Isotopes Disrupt DNA",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "8ee119b3-34ad-4925-a8db-ed09d3f35fc4",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [
    {
      "name": "comparison-frame",
      "slug": null,
      "matchId": "01564305-50e9-46ba-b7e2-03138b0660b9",
      "evidence": "Direct comparison of alpha and beta radiation properties and effects",
      "confidence": 0.9
    }
  ],
  "arcBeats": [
    {
      "to": 12,
      "from": 9,
      "beatId": "c50d4ad9-887f-4c32-8d82-c72b06c2e782",
      "arcName": "The Sequoia Pitch",
      "arcSlug": "sequoia-pitch",
      "beatName": "Problem",
      "beatSlug": "sequoia-pitch-problem",
      "evidence": "The document presents the problem statement, highlighting the limitations of current cancer treatments and the unmet need in NETs.",
      "position": 0,
      "confidence": 0.8,
      "parentBeatName": "Complication",
      "parentBeatSlug": "complication"
    }
  ],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}