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  "documentTitle": "Neumora Therapeutics | IPO Presentation Deck | 32 slides",
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  "notes": "Includes a biological mechanism diagram showing the inhibition of TDP-43 phosphorylation by NMRA-CK1δ.",
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      "text": "Strong Biological Rationale: CK1δ phosphorylates TDP-43, a key driver of TDP-43-driven pathology in ALS",
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      "text": "Pharmacology: Focused on inhibiting CK1δ to reduce pathological TDP-43 and slow ALS progression; regulates tau biology.",
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      "text": "Strong IP Protection: Expect exclusivity through 2043+, based on composition of matter protection plus potential for patent term extension.",
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      "text": "Status: Discovery stage; identified compounds demonstrating CK1δ selectivity, nanomolar potency, and properties consistent with favorable CNS penetration.",
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      "text": "Epidemiology: ~5,000 people diagnosed in U.S. each year and ~16,000 patients in U.S. live with ALS at a given time.",
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      "text": "1) CDC.gov, 2018.",
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      "text": "NMRA-CK1δ for Amyotrophic Lateral Sclerosis",
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