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  "notes": "The slide illustrates the genetic mechanism of the platform, showing how human V, D, and J genes are combined with rat constant regions to facilitate robust immune responses, followed by conversion to fully human antibodies.",
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      "text": "Well-validated transgene design utilizes rodent constant regions for robust immune responses from the B-cell repertoire",
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      "text": "Endogenous Ig genes inactivated\nExpression of full human V gene diversity\nStreamlined conversion into fully human molecule",
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      "text": "Geurts et al. Science 2009; Ménoret et al. Eur J Immunol 2010; Osborn et al. J. Immunol. 2013",
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