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  "documentTitle": "Kymera | Investor Presentation Deck | 60 slides",
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  "authorName": "Kymera",
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  "presentationDate": "2023-08-01 00:00:00",
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  "notes": "Includes a DepMap CRISPR sensitivity chart and a biological process diagram showing the MDM2-p53 feedback loop.",
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      "text": "Dependency of p53WT cells on MDM2",
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      "text": "MDM2 is the E3 Ligase that Modulates p53, the Largest Tumor Suppressor; Cancer genetics: p53 is NOT mutated in almost 50% of tumors; MDM2 overexpression and amplification can inactivate p53; Large opportunity in wide variety of cancers",
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      "text": "KT-253, unlike small molecule inhibitors, overcomes the feedback loop which up-regulates MDM2 production and in doing so more effectively stabilizes the tumor suppressor p53; Broad franchise opportunities available for this mechanism (over 50% of tumors are p53 WT), Kymera is focused on indications with specific sensitivity to degrader mechanism, through a biomarker strategy; Opportunity to translate profile into clinical superiority of degrader over SMI, as has been shown with IRAK4",
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      "text": "MDM2 Degraders In Oncology: KT-253",
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      "text": "Benefits of MDM2 Degradation",
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