{
  "docId": "019de075-ab2a-73e5-980a-7d480707ba09",
  "docSlug": "340a1966b9939070959283ec1665bfbf",
  "documentTitle": "Kymera | Investor Presentation Deck | 60 slides",
  "authorId": "kymera",
  "authorName": "Kymera",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2023-08-01 00:00:00",
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  "pageNumber": 42,
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  "slideType": "market_sizing",
  "function": "size_opportunity",
  "density": "overcrowded",
  "nDataPoints": 16,
  "notes": "Includes a table of prevalence/incidence data and a biological pathway diagram.",
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      "kind": "image",
      "text": "Biological pathway diagram showing STAT3 activation at the cell membrane and translocation to the nucleus",
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      "kind": "list",
      "text": "High degree of validation of JAK-STAT pathway in oncology and immuno-oncology supported by >25k publications; Traditionally undrugged target; First-in-class opportunity to address STAT3 driven pathology across large and diverse indications",
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      "kind": "paragraph",
      "text": "Extrinsic: STAT3 promotes the differentiation and activity of immunosuppressive and endothelial cells, resulting in an immunosuppressive tumor microenvironment",
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      "text": "Intrinsic: Hyperactivation of STAT3 via either receptor signaling, or hotspot mutations promotes gene expression programs involved with survival, proliferation, stemness and metastasis of tumor cells",
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      "text": "U.S. and R.O.W. prevalence and incidence for PTCL, CTCL, LGL-L, and Solid Tumors",
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      "kind": "title",
      "text": "STAT3 Degraders In Oncology: KT-333",
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      "text": "STAT3 Has Unique Tumor Cell Intrinsic and Extrinsic Mechanisms",
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      "name": "Golden Circle",
      "slug": "11-golden-circle",
      "bestFor": "Visionary leadership, brand positioning, mission statements",
      "matchId": "0814ecd6-3302-463c-8283-d9c36bf778b3",
      "evidence": "The deck presents the why, what, and how of STAT3 as a target",
      "position": 2,
      "objective": "Why is STAT3 a good target for oncology?",
      "structure": "The Why (Belief) -> The How (Process) -> The What (Result)",
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