{
  "docId": "019de075-ab2a-73e5-980a-7d480707ba09",
  "docSlug": "340a1966b9939070959283ec1665bfbf",
  "documentTitle": "Kymera | Investor Presentation Deck | 60 slides",
  "authorId": "kymera",
  "authorName": "Kymera",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2023-08-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 23,
  "pageCount": 60,
  "prevPage": 22,
  "nextPage": 24,
  "slideType": "testimonial",
  "function": "illustrate_case",
  "density": "overcrowded",
  "nDataPoints": 25,
  "notes": "Includes before/after photography, clinical efficacy table, and biomarker reduction charts.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de075-ab2a-73e5-980a-7d480707ba09/23",
  "deckHref": "/decks/019de075-ab2a-73e5-980a-7d480707ba09",
  "deckJsonHref": "/decks/019de075-ab2a-73e5-980a-7d480707ba09.json",
  "deckAnchorHref": "/decks/019de075-ab2a-73e5-980a-7d480707ba09#slide-23",
  "components": [
    {
      "bbox": {
        "h": 0.25,
        "w": 0.22,
        "x": 0.26,
        "y": 0.0065
      },
      "kind": "chart",
      "text": "Skin Inflammation Biomarkers (RNAseq) chart showing reduction in various markers.",
      "attrs": null,
      "subkind": "bar-vertical",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "7c60c622-db80-45e3-9d50-5efd52b0ca6f",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.25,
        "w": 0.22,
        "x": 0.03,
        "y": 0.0065
      },
      "kind": "chart",
      "text": "Plasma Cytokines chart showing IL-1B and IL-6 levels over 49 days.",
      "attrs": null,
      "subkind": "line",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "e218a6df-d498-407c-b2de-849b39a3a8d6",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.65,
        "w": 0.45,
        "x": 0.52,
        "y": 0.0025
      },
      "kind": "image",
      "text": "Before and after clinical photographs of the patient's skin.",
      "attrs": null,
      "subkind": "photo",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "0d6cadaf-ee1b-43b2-b506-b7b1a4d1e01b",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.45,
        "x": 0.03,
        "y": 0.0017
      },
      "kind": "list",
      "text": "51-year-old Hispanic/Latino male with severe AD (vIGA-AD) and EASI score of 28.2 at baseline. Previously treated with topical betamethasone 2018-2020",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "36cc454d-b26c-4d5f-ab39-2a060f64c532",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.2,
        "w": 0.45,
        "x": 0.03,
        "y": 0.0038
      },
      "kind": "table",
      "text": "Efficacy Endpoints table showing IGA-AD, EASI, and Peak Pruritis scores from BL to Day 42.",
      "attrs": null,
      "subkind": "data",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "0a6ef316-510a-4b06-8437-4b41ddd9344a",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.04,
        "w": 0.48,
        "x": 0.26,
        "y": 0.08
      },
      "kind": "title",
      "text": "Improvement in Disease Severity from Severe to Mild",
      "attrs": null,
      "subkind": "action-title",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "bf4e29ae-336d-4b08-a096-a242daba0040",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.04,
        "w": 0.42,
        "x": 0.29,
        "y": 0.03
      },
      "kind": "title",
      "text": "AD Case Study: Patient AD-3",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "cbf73a24-2dcb-4096-bd75-810d1322c7b0",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "Before-After-Bridge",
      "slug": "before-after-bridge",
      "agent": "Storyteller",
      "layer": "slide",
      "matchId": "683cd985-458b-473f-9adf-430e4f5d0893",
      "evidence": "Before and after clinical photographs of the patient's skin",
      "confidence": 0.8
    }
  ],
  "frameworks": [],
  "arcBeats": [
    {
      "to": 28,
      "from": 9,
      "beatId": "285a4680-d771-4271-8dc2-ebdc0e60f9a4",
      "arcName": "AIDA",
      "arcSlug": "aida",
      "beatName": "Desire",
      "beatSlug": "aida-desire",
      "evidence": "The slides on Kymera's pipeline and clinical data create desire for the solution",
      "position": 2,
      "confidence": 0.8,
      "parentBeatName": "Evidence",
      "parentBeatSlug": "evidence"
    }
  ],
  "loops": [
    {
      "to": 24,
      "from": 21,
      "name": "Aha Moment",
      "slug": "03-aha-moment",
      "bestFor": "Data-heavy sections, research findings, analytical arguments",
      "matchId": "ba8bc1f1-5cb5-4d72-80c9-6cc8429c2fef",
      "evidence": "The deck presents clinical data that reveals the effectiveness of KT-474",
      "position": 1,
      "objective": "How effective is KT-474 in clinical trials?",
      "structure": "The Problem/Question -> What the Data Shows -> The Insight",
      "confidence": 0.7,
      "description": "Establish a tension, present data, then deliver the insight that changes everything"
    }
  ],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}