{
  "docId": "019de075-8d44-7401-b489-ee436db9a207",
  "docSlug": "66ec60e76d61a423395d466c32dc56fb",
  "documentTitle": "Exscientia | Investor Presentation Deck | 75 slides",
  "authorId": "exscientia",
  "authorName": "Exscientia",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2023-08-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 57,
  "pageCount": 75,
  "prevPage": 56,
  "nextPage": 58,
  "slideType": "solution",
  "function": "present_solution",
  "density": "overcrowded",
  "nDataPoints": 20,
  "notes": "The slide uses a Pareto front to illustrate the trade-off between CNS score and Potency, highlighting the selection of 'unattractive' compounds.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de075-8d44-7401-b489-ee436db9a207/57",
  "deckHref": "/decks/019de075-8d44-7401-b489-ee436db9a207",
  "deckJsonHref": "/decks/019de075-8d44-7401-b489-ee436db9a207.json",
  "deckAnchorHref": "/decks/019de075-8d44-7401-b489-ee436db9a207#slide-57",
  "components": [
    {
      "bbox": {
        "h": 0.55,
        "w": 0.5,
        "x": 0.07,
        "y": 0.3
      },
      "kind": "chart",
      "text": "Scatter plot of CNS Score vs Potency with Pareto front",
      "attrs": null,
      "subkind": "scatter",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "17a31734-4162-4c7a-823a-c190adf7d0bd",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.4,
        "x": 0.1,
        "y": 0.85
      },
      "kind": "legend",
      "text": "20 compounds (square) are selected by active learning chemical coverage; other compounds (circles) were not selected",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "5ad3d732-1653-4360-9856-153869eca216",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.6,
        "w": 0.35,
        "x": 0.58,
        "y": 0.26
      },
      "kind": "list",
      "text": "Our active learning approach selected compounds both close to and away from the pareto front (dotted arch) using a combination of MPO and coverage score. \"Seemingly unattractive\" compounds, 1&2, were identified, away from the pareto front. 1&2 were non-optimal on any predicted property but were structurally different. Structures were synthesised and tested – this new scaffold providing a better starting point to achieve the TPP. Further cycles of design refined hits to produce ‘539",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "2c55b1f0-4bb9-4669-b2d5-725b08c588d4",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.1,
        "w": 0.25,
        "x": 0.35,
        "y": 0.25
      },
      "kind": "source-note",
      "text": "Pareto front identifies the “best” molecules to make and test but these are not the most information rich",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "d7ec646d-ff21-4018-ad0d-b93de7664aeb",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.7,
        "x": 0.07,
        "y": 0.13
      },
      "kind": "title",
      "text": "Counterintuitive selection went against preconceptions to break dogma",
      "attrs": null,
      "subkind": "action-title",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "35409996-87f1-4838-822e-f87f785ae5d2",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.5,
        "x": 0.07,
        "y": 0.06
      },
      "kind": "title",
      "text": "Active learning enabled breakthrough for ‘539",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "589ac1ed-5aa4-4c62-a73e-bbf0b55248be",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [
    {
      "name": "pareto-principle-80-20",
      "slug": null,
      "matchId": "defced31-0615-4906-aaea-9322a5091380",
      "evidence": "The slide explicitly references a 'Pareto front' to explain the trade-off in compound selection.",
      "confidence": 0.9
    }
  ],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}