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  "notes": "The slide uses a combination of bar charts and scatter plots to demonstrate the inverse relationship between ABS and TIS.",
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      "text": "Bar charts comparing TIS Low vs TIS High for Breast, Pancreas, Kidney, and Lung",
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      "text": "Higher adenosine as determined by ABS correlates to lower inflammation in the tumour as determined by the tumour inflammation signature (TIS)\nPatients who have high ABS have a low TIS score\nTIS is a predictive signature for anti-PD-1 response2",
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      "text": "Biological validation of ABS in a larger sample cohort (TCGA1):",
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      "text": "1. The Cancer Genome Atlas Project (TCGA) dataset, NCI\n2. Damotte et al, Journal of Translational Medicine (2019); Vladimer et al, ESMO I-O (2022)",
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