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  "documentTitle": "Chimerix | Investor Presentation Deck | 43 slides",
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      "text": "ONC201 reverses H3 K27me3-loss in H3 K27M glioma patients' tumors",
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      "text": "Removal of H3 K27M mutation results in reversal H3 K27me3-loss and prolonged OS in mouse models of H3 K27M glioma",
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      "text": "H3 K27M causes loss of global H3 K27 trimethylation (H3 K27me3-loss)",
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      "text": "https://www.cell.com/trends/cancer/fulltext/S2405-8033%292930202-X; Zhang et al, Science Translational Medicine, 2023; Koshmann et al, AACR 2023",
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      "text": "H3 K27M central characteristic reversed by ONC201",
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